Results 51 to 60 of about 11,434 (195)

Polymyxins: To Combine or Not to Combine?

, 2019
Polymyxins have been a mainstay for the treatment of extensively drug resistant (XDR) Gram-negative bacteria for the past two decades. Many questions regarding the clinical use of polymyxins have been answered, but whether the administration of ...
Federico Perez, Robert A. Bonomo, Nadim G. El Chakhtoura, Nadim G. El Chakhtoura, Mohamad Yasmin, Robert A. Bonomo   +5 more
core   +1 more source

Semisynthetic polymyxins with potent antibacterial activity and reduced kidney cell toxicity [PDF]

, 2023
The growing incidence of infections caused by multi-drug resistant Gram-negative bacteria has led to an increased use of last-resort antibiotics such as the polymyxins.
Wesseling, Charlotte M. J., Masereeuw, Rosalinde, Lysenko, Vladyslav, Barnes, Devon, Martin, Nathaniel I., Chaudhuri, Samhita, Slingerland, Cornelis J.   +6 more
core  

Potential Synergy of Fluoxetine and Antibacterial Agents Against Skin and Soft Tissue Pathogens and Drug-Resistant Organisms

Antibiotics
Background/Objectives: The feasibility of repurposing selective serotonin reuptake inhibitors as adjunctive antibacterial agents is an area of current investigation.
Samar A. Ahmed, Rondelle L. Jordan, Roslyn Rivkah Isseroff, Justin R. Lenhard   +3 more
doaj   +1 more source

Colistin Use in European Livestock: Veterinary Field Data on Trends and Perspectives for Further Reduction

Veterinary Sciences, 2022
Polymyxin E (colistin) is a medically important active substance both in human and veterinary medicine. Colistin has been used in veterinary medicine since the 1950s.
Wiebke Jansen, Jobke van Hout, Jeanine Wiegel, Despoina Iatridou, Ilias Chantziaras, Nancy De Briyne   +5 more
doaj   +1 more source

Potential toxicity of polymyxins in human lung epithelial cells [PDF]

, 2017
Inhaled polymyxins are of considerable utility in achieving optimal exposure in the respiratory tract for the treatment of lung infections caused by multidrug-resistant Gram-negative pathogens.
Lin, Yu-Wei, Yun, Bo, Mohammad A. K. Azad, Zhou, Qi Tony, Azad, Mohammad A K, Nowell, Cameron J, Yu-Wei Lin, Cameron J. Nowell, Kim Chan, Tony Velkov, Velkov, Tony, Fanfan Zhou, Maizbha U. Ahmed, Jian Li, Bo Yun, Chan, Kim, Qi Tony Zhou, Ahmed, Maizbha U, Zhou, Fanfan, Li, Jian   +19 more
core   +1 more source

Polymyxins resistance: old antimicrobials, last therapeutic options

Revista de Epidemiologia e Controle de Infecção, 2012
Polymyxins are polypeptide antimicrobials that act in the cell membranes and promote decrease of the cell wall integrity. These antimicrobials are used in the clinical practice for treatment of the multi-drug resistant Gram negative bacilli infections ...
Raquel Girardello, Ana Cristina Gales
doaj   +1 more source

Prevalence of carbapenemase-producing Klebsiella pneumonia in Gomel Region of Belarus and their sensitivity to antibiotics, antibiotic combinations, and decontaminants

Инфекция и иммунитет, 2020
Here, we characterized in public health organizations prevalence of carbapenemase-producing Klebsiella pneumoniae, sensitivity to antimicrobial agents (AMAs), combined antimicrobial agents, and decontaminants.
D. V. Tapalski, O. I. Savchenko, N. A. Bonda   +2 more
doaj   +1 more source

Co‐Infection of Brucella canis and Brucella melitensis in a Domestic Dog With Zoonotic Transmission to Human, China

Animal Research and One Health, EarlyView.
Source attribution figure for human and dogs Brucella canis infections. ABSTRACT We report a rare occurrence of genetic material from both Brucella canis and B. melitensis detected in a domesticated dog from Jiangsu Province, China. The detection was confirmed through serological assays, quantitative PCR (qPCR), metagenomic and genomic sequencing ...
Shengxin Ge, Jian Xu, Qingchun Shen, Jiabo Ding, Xiaowen Yang   +4 more
wiley   +1 more source

A case series of necrotizing periodontal diseases in hospitalized patients: What hasn't been said yet?

Clinical Advances in Periodontics, EarlyView.
Abstract Background Necrotizing periodontal diseases (NPDs) are uncommon and severe inflammatory conditions characterized by tissue necrosis, painful ulceration, and rapid clinical progression, frequently associated with systemic immunosuppression. Limited data exist regarding their clinical presentation and management in hospital settings.
Osmaria Letthycia Carvalho Leal, Fernanda Bortolotto, Mariana Cristina Manoel, Gabriela Silveira de Araújo, Ana Carolina Fragoso Motta, Leandro Dorigan de Macedo, Lara Maria Alencar Ramos Innocentini, Joab Cabral Ramos, Isabel Schausltz Pereira Faustino   +8 more
wiley   +1 more source

Genomic Insights Into Spatiotemporal Dynamics of Acquired Azithromycin Resistance Genes in Salmonella Strains Worldwide

Food Safety and Health, EarlyView.
ABSTRACT Azithromycin has been used for clinical invasive infections caused by fluoroquinolone‐ and third‐generation cephalosporin‐resistant Salmonella, and mass drug administration with azithromycin has been used to reduce under‐5 mortality in children in some countries.
Yuhang Pei, Mengqi Qu, Ziru Yang, Xuebin Xu, Yanan Wang   +4 more
wiley   +1 more source