Results 71 to 80 of about 11,434 (195)

Evolutionary and Epidemiological Characterization of Multidrug‐Resistant Escherichia coli Isolated From Pangolins in China

Integrative Zoology, EarlyView.
ABSTRACT Malayan pangolin populations have fallen to a critically endangered level, and illegal trafficking of wild pangolins is a global problem. Little is known about antimicrobial‐resistant bacteria (MDRB) harbored by pangolins, although pangolins are frequently consumed as food or used in traditional medicine. In this study, we report for the first
Yawen Wang, Xue Wang, Jianan Zhao, Jun Zeng, Shijia Hu, Fang Ji, Guoying Dong, Hongxuan He, Chengmin Wang   +8 more
wiley   +1 more source

Interventions on Metabolism: Making Antibiotic-Susceptible Bacteria

mBio, 2017
Antibiotics act on bacterial metabolism, and antibiotic resistance involves changes in this metabolism. Interventions on metabolism with drugs might therefore modify drug susceptibility and drug resistance.
Fernando Baquero, José-Luis Martínez
doaj   +1 more source

Polypropylene Nanoplastic Exposure to Respiratory Epithelial Barrier‐On‐Chip and Interfacial Interactions With Human Serum Albumin

Allergy, EarlyView.
Exposure to 305 nm PP NPs significantly disrupts the airway barrier‐on‐chip, reducing TEER, suppressing ZO‐1/ACE2 expression, and triggering ROS‐mediated apoptosis. In biological media, PP NPs exhibit a biphasic adsorption pattern, leading to the formation of a protein corona that increases their size to 364 nm.
Omur Sert, Eyup Bilgi, Reyhan Coban, Pelin Saglam‐Metiner, Basar Dogan, Zeynep Imir‐Tekneci, Suleyman Selim Cinaroglu, Ozlem Goksel, Ceyda Oksel Karakus, Ozlem Yesil‐Celiktas   +9 more
wiley   +1 more source

Cellular uptake and localization of polymyxins in renal tubular cells using rationally designed fluorescent probes [PDF]

, 2015
Polymyxins are cyclic lipopeptide antibiotics that serve as a last line of defense against Gram-negative bacterial superbugs. However, the extensive accumulation of polymyxins in renal tubular cells can lead to nephrotoxicity, which is the major dose ...
Thompson, Philip E, Yun, Bo, Azad, Mohammad A K, Nowell, Cameron J, Roberts, Kade D, Nation, Roger L, Li, Jian, Velkov, Tony   +7 more
core   +1 more source

Challenges in the Detection of Polymyxin Resistance: From Today to the Future

Microorganisms
Antimicrobial resistance is known to be one of the greatest global threats to human health, and is one of the main causes of death worldwide. In this scenario, polymyxins are last-resort antibiotics to treat infections caused by multidrug-resistant ...
Rebeca Siqueira Rubens, Isabel de Souza Andrade Arruda, Rosane Mansan Almeida, Yanna Karla de Medeiros Nóbrega, Maiara dos Santos Carneiro, Tanise Vendruscolo Dalmolin   +5 more
doaj   +1 more source

Clinical outcomes of empirical topical nifuratel or nitrofurantoin in Streptococcus pyogenes vulvovaginitis: A retrospective study

International Journal of Gynecology &Obstetrics, EarlyView.
Marek Stefan, Kristyna Krogh, Jaroslava Zikova, Marta Novackova, Marcela Krutova   +4 more
wiley   +1 more source

Aptamer‐mediated outer membrane destabilization overcomes low permeability resistance in Pseudomonas aeruginosa

The FEBS Journal, EarlyView.
DNA aptamers, Apt 60 and Apt 173, target the BamA protein to compromise outer membrane integrity in Pseudomonas aeruginosa, making it susceptible to Azithromycin, an antibiotic that is otherwise poorly effective due to the low‐permeability membrane.
Rupany Selvam, Michelle Khai Khun Yap, Rafael Giacomazzi, Sérgio F. Sousa, Hock Siew Tan   +4 more
wiley   +1 more source

Potent activity of polymyxin B is associated with long-lived super-stoichiometric accumulation mediated by weak-affinity binding to lipid A

Nature Communications
Polymyxins are gram-negative antibiotics that target lipid A, the conserved membrane anchor of lipopolysaccharide in the outer membrane. Despite their clinical importance, the molecular mechanisms underpinning polymyxin activity remain unresolved.
Kerry R. Buchholz, Mike Reichelt, Matthew C. Johnson, Sarah J. Robinson, Peter A. Smith, Steven T. Rutherford, John G. Quinn   +6 more
doaj   +1 more source

IMPACT OF ANTIMICROBIAL USE ON RESISTANCE IN GRAM-NEGATIVE BACILLI: A SECONDARY ANALYSIS OF ANVISA DATA (2019–2023) IN HOSPITALIZED ADULTS IN ICUS WITH CATHETER-ASSOCIATED URINARY TRACT INFECTION (CA-UTI) AND LABORATORY-CONFIRMED CENTRAL LINE-ASSOCIATED BLOODSTREAM INFECTION (CLABSI)

Brazilian Journal of Infectious Diseases
Introduction/Objectives: Antimicrobial resistance (AMR) has a major impact on healthcare, being associated with worse clinical outcomes and higher hospital costs.
Matheus Negri Boschiero, Josiane Trevisol Leal, Kenzo Sano Shine, Magda Machado de Miranda Costa, Maria Dolores Santos da Purificação Nogueira, Mara Rúbia Santos Gonçalves, Lilian de Souza Barros, Luciana Silva da Cruz de Oliveira, Ana Cristina Gales   +8 more
doaj   +1 more source

The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1

The FEBS Journal, EarlyView.
ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu, Maximilian J. L. J. Fürst, Oscar P. Kuipers   +2 more
wiley   +1 more source