Results 81 to 90 of about 10,639 (243)

Challenges in the Detection of Polymyxin Resistance: From Today to the Future

Microorganisms
Antimicrobial resistance is known to be one of the greatest global threats to human health, and is one of the main causes of death worldwide. In this scenario, polymyxins are last-resort antibiotics to treat infections caused by multidrug-resistant ...
Rebeca Siqueira Rubens, Isabel de Souza Andrade Arruda, Rosane Mansan Almeida, Yanna Karla de Medeiros Nóbrega, Maiara dos Santos Carneiro, Tanise Vendruscolo Dalmolin   +5 more
doaj   +1 more source

The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1

The FEBS Journal, EarlyView.
ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu, Maximilian J. L. J. Fürst, Oscar P. Kuipers   +2 more
wiley   +1 more source

Polymyxins: review with emphasis on nephrotoxicity [PDF]

, 2009
As polimixinas são antibióticos polipeptídeos com potente ação sobre várias bactérias gram-negativas. O seu uso foi praticamente abandonado entre 1970 e 1980, em virtude do aparecimento de drogas com menor toxicidade.
BURDMANN, Emmanuel A, MENDES, Carlos Alberto Caldeira   +1 more
core   +1 more source

Potent activity of polymyxin B is associated with long-lived super-stoichiometric accumulation mediated by weak-affinity binding to lipid A

Nature Communications
Polymyxins are gram-negative antibiotics that target lipid A, the conserved membrane anchor of lipopolysaccharide in the outer membrane. Despite their clinical importance, the molecular mechanisms underpinning polymyxin activity remain unresolved.
Kerry R. Buchholz, Mike Reichelt, Matthew C. Johnson, Sarah J. Robinson, Peter A. Smith, Steven T. Rutherford, John G. Quinn   +6 more
doaj   +1 more source

IMPACT OF ANTIMICROBIAL USE ON RESISTANCE IN GRAM-NEGATIVE BACILLI: A SECONDARY ANALYSIS OF ANVISA DATA (2019–2023) IN HOSPITALIZED ADULTS IN ICUS WITH CATHETER-ASSOCIATED URINARY TRACT INFECTION (CA-UTI) AND LABORATORY-CONFIRMED CENTRAL LINE-ASSOCIATED BLOODSTREAM INFECTION (CLABSI)

Brazilian Journal of Infectious Diseases
Introduction/Objectives: Antimicrobial resistance (AMR) has a major impact on healthcare, being associated with worse clinical outcomes and higher hospital costs.
Matheus Negri Boschiero, Josiane Trevisol Leal, Kenzo Sano Shine, Magda Machado de Miranda Costa, Maria Dolores Santos da Purificação Nogueira, Mara Rúbia Santos Gonçalves, Lilian de Souza Barros, Luciana Silva da Cruz de Oliveira, Ana Cristina Gales   +8 more
doaj   +1 more source

Clinical outcomes of lateral ear canal resection performed in routine clinical practice for chronic otitis externa in dogs: a retrospective descriptive study of 58 ears (2016‐2025)

Journal of Small Animal Practice, EarlyView.
Objectives To retrospectively evaluate the long‐term clinical outcomes of lateral ear canal resection performed as part of routine clinical practice for chronic otitis externa in dogs, and to re‐evaluate the practical utility of lateral ear canal resection from the perspective of contemporary treatment goals emphasising long‐term maintenance of a ...
K. Kiriki, A. Yabuzoe, K. Iyori
wiley   +1 more source

Metabolic Responses to Polymyxin Treatment in Acinetobacter baumannii ATCC 19606: Integrating Transcriptomics and Metabolomics with Genome-Scale Metabolic Modeling

mSystems, 2019
Multidrug-resistant (MDR) Acinetobacter baumannii has emerged as a very problematic pathogen over the past decades, with a high incidence in nosocomial infections. Discovered in the late 1940s but abandoned in the 1970s, polymyxins (i.e., polymyxin B and
Yan Zhu, Jinxin Zhao, Mohd Hafidz Mahamad Maifiah, Tony Velkov, Falk Schreiber, Jian Li   +5 more
doaj   +1 more source

Ocular Pharmacokinetics of Topical Chloramphenicol in Dogs: Effects of Concentration and Vehicle Formulation

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT This study compared tear film exposure and retention of four chloramphenicol ophthalmic formulations in dogs, evaluating the effects of drug concentration (0.2% to 5%) and vehicle type (solution vs. ointment). Eight healthy dogs were enrolled in a randomized paired‐eye crossover study consisting of two sessions with a 7‐day washout.
Bar Fruchter, Oren Pe'er, Shir Gonen, Lionel Sebbag   +3 more
wiley   +1 more source

Regulation of the Yersinia pseudotuberculosis Type III Secretion System by the CpxAR Two‐Component System

Molecular Microbiology, EarlyView.
Host tissue cues including temperature, oxygen, and iron availability regulate expression of the Yersinia type III secretion system (T3SS) master regulator LcrF. We found that CpxR inhibits LcrF through an indirect, multi‐factorial mechanism and identified the osmolarity‐sensing OmpR/EnvZ system as an additional regulator of LcrF, highlighting ...
Karen Hug, Erin Mettert, Melissa Estrada Escobar, Cristina Vargas Vazquez, David Balderas, Sarvind Tripathi, Laya Ashley, Patricia J. Kiley, Victoria Auerbuch   +8 more
wiley   +1 more source

Design and Evaluation of Novel Polymyxin Fluorescent Probes

Sensors, 2017
Polymyxins (polymyxin B and colistin) are cyclic lipopeptide antibiotics that serve as a last-line defence against Gram-negative “superbugs”. In the present study, two novel fluorescent polymyxin probes were designed through regio-selective modifications
Bo Yun, Kade D. Roberts, Philip E. Thompson, Roger L. Nation, Tony Velkov, Jian Li   +5 more
doaj   +1 more source