tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay. [PDF]
Elife, 2019 Yeast tRNA ligase (Trl1) is an essential trifunctional enzyme that catalyzes exon-exon ligation during tRNA biogenesis and the non-conventional splicing of HAC1 mRNA during the unfolded protein response (UPR).
Peschek J, Walter P.
europepmc +3 more sources
Acanthamoeba castellanii exhibits intron retention during encystment [PDF]
, 2022 Intron retention (IR) refers to the mechanism of alternative splicing in which an intron is not excised from the mature transcript. IR in the cosmopolitan free-living amoeba Acanthamoeba castellanii has not been studied.
De Obeso Fernandez Del Valle, Alvaro +2 more
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Structural and mutational analysis of archaeal ATP-dependent RNA ligase identifies amino acids required for RNA binding and catalysis. [PDF]
Nucleic Acids Res, 2016 An ATP-dependent RNA ligase from Methanobacterium thermoautotrophicum (MthRnl) catalyzes intramolecular ligation of single-stranded RNA to form a closed circular RNA via covalent ligase-AMP and RNA-adenylylate intermediate.
Gu H +6 more
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, 2022 筑波大学University of Tsukuba博士（人間生物学）Doctor of Philosophy in Human Biology2022doctoral ...
Liu, Yancheng +2 more
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Enzymes involved in DNA ligation and end-healing in the radioresistant bacterium [PDF]
, 2007 BACKGROUND: Enzymes involved in DNA metabolic events of the highly radioresistant bacterium Deinococcus radiodurans are currently examined to understand the mechanisms that protect and repair the Deinococcus radiodurans genome after extremely high doses ...
Blasius, M +3 more
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T4 RNA Ligase 2 truncated active site mutants: improved tools for RNA analysis [PDF]
, 2011 Background T4 RNA ligases 1 and 2 are useful tools for RNA analysis. Their use upstream of RNA analyses such as high-throughput RNA sequencing and microarrays has recently increased their importance.
Sebastien Viollet +4 more
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hnRNP A1 interacts with the genomic and subgenomic RNA promoters of Sindbis virus and is required for the synthesis of G and SG RNA [PDF]
, 2010 Background Sindbis virus (SV) is the prototype of alphaviruses which are a group of widely distributed human and animal pathogens. Heterogeneous nuclear ribonucleoprotein (hnRNP) A1 is an RNA-binding protein that shuttles between the nucleus ...
Hongxin Gui +4 more
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Mitochondrial dysfunction and immune activation are detectable in early Alzheimer's disease blood. [PDF]
, 2016 PublishedJournal ArticleResearch Support, Non-U.S. Gov'tAlzheimer's disease (AD), like other dementias, is characterized by progressive neuronal loss and neuroinflammation in the brain.
AddNeuroMed Consortium +19 more
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Several Hfq-dependent alterations in physiology of Yersinia enterocolitica O:3 are mediated by derepression of the transcriptional regulator RovM [PDF]
, 2017 In bacteria, the RNA chaperone Hfq enables pairing of small regulatory RNAs with their target mRNAs and therefore is a key player of post-transcriptional regulation network. As a global regulator, Hfq is engaged in the adaptation to external environment,
Bengoechea, José A +5 more
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Dual targeting of the tRNA nucleotidyltransferase in plants: not just the signal [PDF]
, 2007 Enzymes involved in tRNA maturation are essential for cytosolic, mitochondrial, and plastid protein synthesis and are therefore localized to these different compartments of the cell.
Gu, Jun +5 more
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