Results 161 to 170 of about 9,001 (206)
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Alkylation of Synthetic Polynucleotides
Science, 1964The synthetic polynucleotides may be used as models for the effects of alkylating agents on nucleic acid. Alkylation of polyadenylic acid with methyl methanesulfonate yields a polymer methylated in the one-position of adenine. This alteration in structure produces marked changes in physical properties and decreases the capacity to code for polylysine ...
D B, LUDLUM, R C, WARNER, A J, WAHBA
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Mechanism of polynucleotide phosphorylase
Biochemistry, 1989The de novo polymerization of RNA initiated by polynucleotide phosphorylase from nucleoside diphosphates was examined. End group analysis performed under conditions designed to specifically end label the polymer revealed no evidence for a 5'-pyrophosphate-terminated polymer.
M, Sulewski +3 more
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Synthetic Analogues of Polynucleotides
Nature, 1968ANALOGUES of purines and pyrimidines have been used as antimetabolites1. Some of these have been converted into their nucleosides or nucleotides which also act as antimetabolites2. Analogues of nucleosides in which D-ribose or 2-deoxy-D-ribose is replaced by another carbohydrate or carbohydrate analogue have also been extensively studied2.
M H, Halford, A S, Jones
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Polynucleotide Phosphorylase and the T3SS
2007Low temperatures as well as encounters with host phagocytes are two stresses that have been relatively well studied in many species of bacteria. The exoribonuclease polynucleotide phosphorylase (PNPase) has previously been shown to be required by several species of bacteria, including Yersinia, for low-temperature growth. We have shown that PNPase also
Jason A, Rosenzweig, Kurt, Schesser
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Biologic Properties of Polynucleotides. II. The Anticoagulant Properties of Polynucleotides
Blood, 1964Abstract Polyinosinic and polyguanylic acids have been found to possess anticoagulant properties. Other synthetic homoribopolynucleotides, as well as naturally occurring RNAs and DNAs are devoid of such properties. Polyinosinic acid will prolong the silicone recalcification time, Quick one-stage prothrombin time, and Russel Viper Venom ...
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Methylation in the Study of Polynucleotides
Nature, 1949ALTHOUGH detailed knowledge of the components of pentose nucleic acids is still incomplete, considerable effort over a long period has been directed towards the problem of the mode of union of the constituent nucleosides. It was early recognized that these units are linked through phosphoric acid residues, and the precise manner in which this takes ...
A S, ANDERSON, G R, BARKER, K R, FARRAR
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Hypochromicity of oligo- and polynucleotides
Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects, 1962Abstract 1. 1. Syntheses of dinucleoside phosphates containing 6-dimethylaminopurine are described. The ultraviolet-absorption properties of these compounds show that hydrogen bonding is not a direct cause of hypochromicity. 2. The properties of chemically synthesised oligoguanylic acids and of dinucleoside 5′-pyrophosphates are examined and the ...
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The interaction of polynucleotides with cations
Biochimica et Biophysica Acta, 1959Abstract The interaction with divalent cations of the synthetic polynucleotides, polyadenylic acid and polyuridylic acid, has been studied by conductiometric titration. It is shown that further binding of divalent cation by polynucleotide ceases when one equivalent of cation has been added per mole of polymer phosphate, and that the titration curve ...
G, FELSENFELD, S, HUANG
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The Synthesis of Oligo‐ and Polynucleotides
Angewandte Chemie International Edition in English, 1966AbstractProblems and results of the synthesis of oligonucleotides are reviewed. The central role of the nucleic acids in biochemistry is a challenge to synthesize nucleic acids of known base sequence and chain length. Oligomers with various sequences of up to 12 members and homo‐oligomers with a maximum chain length of 30 nucleotides can be obtained by
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The hypochromism of helical polynucleotides
Journal of Molecular Biology, 1962The hypochromism of the 260 mμ. absorption band of helical DNA is its lower absorbance, per base group, compared to the absorbance of the mononucleotides. The hypochromism of DNA has been calculated as a function pf the base composition and sequence. The oscillator strengths, transition monopoles and transition moments for the π→π* transitions of the ...
H, DEVOE, I, TINOCO
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