Results 91 to 100 of about 89,285 (227)

Slow Transit Constipation: Pathophysiological Perspectives and Management Updates

Journal of Digestive Diseases, EarlyView.
Slow transit constipation (STC) is a complex neuromuscular disorder driven by interstitial cells of Cajal (ICCs) loss and enteric neuropathy. Diagnosis relies on objective transit testing while excluding pelvic floor dysfunction. Management follows a stepwise, phenotype‐driven approach, progressing from conventional laxatives to emerging targeted ...
Athanasios Syllaios, Stavros P. Papadakos, Alexandros Ioannou, Maximos Frountzas, Dimosthenis Michelakis, Dimitrios Patsouras, Spyridon Dritsas, Manousos‐Georgios Pramateftakis, Dimitrios Schizas   +8 more
wiley   +1 more source

Pharmacy services and role development in UK general practice: a cross‐sectional survey

International Journal of Pharmacy Practice, EarlyView., 2020
Abstract Background The ‘Clinical Pharmacists in General Practice’ (CPGP) pilot provided a template for general practice pharmacy professionals’ (GPPPs) roles encouraging NHS England to fund >2000 practice‐based pharmacists. However, many GPPPs work outside the CPGP initiative and little is known about the services they provide.
Vilius Savickas, Ellie Foreman, Anmol Ladva, Sukvinder K. Bhamra, Ravi Sharma, Sarah A. Corlett   +5 more
wiley   +1 more source

Predicting Cognitive Change During Treatment for Inpatient Depression: Secondary Analysis From a Randomized Controlled Trial

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Introduction Individuals hospitalized with depression are particularly impacted by cognitive impairment. Identifying variables that predict improvements in cognition across treatment may inform more targeted and effective treatment approaches. We conducted secondary analyses to investigate baseline predictors of objective cognitive change in a
Zoe A. Odering, Jennifer Jordan, Cameron J. Lacey, Christopher M. Frampton, Richard J. Porter, Katie M. Douglas   +5 more
wiley   +1 more source

The Oldest Known Case of SCA6: Diagnostic Insights from a 101‐Year‐Old Woman with Progressive Ataxia

Movement Disorders Clinical Practice, EarlyView.
Nicolas Labaure, Katherine Longardner
wiley   +1 more source

The association of methadone use with physical function and frailty among persons who inject drugs

Addiction, EarlyView.
Abstract Background and Aims Persons who inject drugs (PWID) experience a high burden of early‐onset frailty, primarily due to multifactorial causes such as infections (human immunodeficiency virus [HIV], hepatitis C virus [HCV]), substance use, and polypharmacy.
Grace L. Kulik, Hsing‐Yu Hsu, Jacqueline Rudolph, Yutong Jiang, Kristine M. Erlandson, Damani A. Piggott, Shruti Mehta, Jeremy D. Walston, Gregory Kirk, Todd T. Brown, Jing Sun   +10 more
wiley   +1 more source

Multimorbidity: Technical Series on Safer Primary Care [PDF]

, 2016
No abstract ...
Fischbacher-Smith, Denis, Furler, John, Mercer, Stewart, Moffat, Keith, Sanci, Lena   +4 more
core  

What anabolic–androgenic steroids reveal about the limits of current harm reduction models

Addiction, EarlyView.
Abstract Background Harm reduction has largely been shaped by responses to psychoactive drug use where the most urgent harms are acute. These models focus on overdose, blood‐borne viruses, and rapid‐onset toxicity related harms. When applied wholesale to anabolic–androgenic steroids (AAS), they obscure the distinctive pharmacology, consumer typologies,
Timothy Piatkowski, Jason M. Nagata, Suzanne Nielsen   +2 more
wiley   +1 more source

Peri‐operative pain management in major lower extremity amputation in vascular Surgery: a UK anaesthetic and vascular surgery Delphi consensus study*

Anaesthesia, EarlyView.
Summary Introduction Major lower extremity amputations occurring secondary to vascular disease remain prevalent worldwide. Pain surrounding these procedures is complex, multifactorial and associated with poor functional and psychosocial outcomes. The evidence base informing pain management approaches in major lower extremity amputations remain largely ...
Thanapon Ekkunagul, Caitlin Sara MacLeod, Anna Celnik, John Chalmers, Ross Thomson, Alan J. R. Macfarlane, David Bosanquet, John Nagy, Patrice Forget, the Delphi expert panel, Abhijoy Chakladar, Ahmed Abidia, Alan Fayaz, Alan Macfarlane, Alasdair Taylor, Alastair Thomson, Alexander Bell, Amy Sadler, Andrea Harvey, Andrew Mitchell, Andrew Tambyraja, Andrew William Garnham, Andrey Varvinskiy, Ankur Thapar, Anna Celnik, Caroline Curry, Catherine Western, Catriona Semple, Christopher G Davies, Craig Forrest, David Bosanquet, Denis Harkin, Diane Rosemary Hildebrand, Douglas James MacKenzie, Emma Elizabeth Florence Scott, Emma Jannine Baird, Ferdinand Serracino‐Inglott, Fiona Myint, Frances Kent, Francesco Torella, Gareth Harrison, George A. Antoniou, George Edward Smith, Graeme A McLeod, Ian Chetter, Indran Raju, John Chalmers, John Nagy, John O'Donoghue, Jonathan Paul Seeley, Kaji Sritharan, Keith Hussey, Keith Jones, Kersten Morgan Bates, Kevin Graham Mercer, Kieran Murphy, Lisa Anne Grimes, Matt Metcalfe, Maureen Sweeney, Michael McCusker, Michael Neil, Michelle Lamont, Mohamed Elsherif, Nat Haslam, Naveeta Maini, Nicholas Stuart Greaves, Patrick Coughlin, Patrice Forget, Peter Merjavy, Robert Hinchliffe, Rob Sayers, Ross Thomson, Russell William Jamieson, Sachin R Kulkarni, Sandeep Bahia, Sandip Nandhra, Serena Goon, Tanim Siddiqui, Tim Stansfield, Vanessa Fludder, Vikas Kaura, Vishal Gupta   +81 more
wiley   +1 more source

Frailty Is Associated With All‐Cause and Acute Hospitalisations During 18 Months Follow‐Up in Older Patients With Inflammatory Bowel Disease

Alimentary Pharmacology &Therapeutics, EarlyView.
The results of a geriatric assessment in older patients with IBD were associated with adverse health outcomes. Frailty, reflected by severe deficits in geriatric assessment, was independently associated with all‐cause and acute hospitalisations in older patients with IBD. ABSTRACT Background Guidelines recommend considering frailty in the management of
Anne B. Fons, Vera E. R. Asscher, Rogier J. L. Stuyt, A. Martine C. Baven‐Pronk, Sander van der Marel, Rutger J. Jacobs, Jeoffrey J. L. Haans, Andrea E. van der Meulen‐de Jong, Simon P. Mooijaart, Kees. J. Kalisvaart, P. W. Jeroen Maljaars   +10 more
wiley   +1 more source

Economic burden of hidradenitis suppurativa based on healthcare resource utilization: German claims data analysis

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives Hidradenitis suppurativa (HS) is a chronic, debilitating skin disease affecting approximately 0.1% of the German population. Patients with HS require substantial healthcare resource utilization. This study aimed to assess the economic burden associated with HS in Germany.
Falk G. Bechara, Tanja Tran, Sandeep Kiri, Romy Bley, Kathrin Schlüter, Claudia Grellmann, Sima Melnik, Sylke Schneider‐Burrus   +7 more
wiley   +1 more source