Results 41 to 50 of about 54,184 (288)

cuteHap: Haplotype‐Aware Structural Variant Detection in Phased Long‐Read Sequencing Data

Advanced Science, EarlyView.
cuteHap is a haplotype‐aware structural variant detection method designed for phased long‐read sequencing. By employing self‐adaptive clustering and credibility‐prioritized beam search algorithms, cuteHap generates accurate haplotype‐resolved calls and outperforms state‐of‐the‐art tools.
Shuqi Cao, Yadong Liu, Miao Cui, Runtian Gao, Weimin Guo, Guohua Wang, Yadong Wang, Tao Jiang   +7 more
wiley   +1 more source

Establishment and Biological Characteristics Analysis of a Hybrid Culter Lineage from Megalobrama amblycephala (♀) and Culter alburnus (♂)

Animals
Culter alburnus (topmouth culter, TC) is extensively distributed in various rivers and lakes in China. As a widely adaptive fish species, they have significant economic value and special ecological roles.
Jinhui Huang, Yingying Yang, Jiawang Huang, Xiaoyu Huang, Jiaxuan Zhu, Yanran Xiong, Lang Qin, Hongxuan Liang, Ming Wen, Yuxiang Wang, Xu Huang, Fangzhou Hu, Shi Wang, Chang Wu, Shaojun Liu   +14 more
doaj   +1 more source

Ploidy Status of Ovarian Cancer Cell Lines and Their Association with Gene Expression Profiles

Biomolecules, 2023
As a cancer type potentially dominated by copy number variations, ovarian cancer shows hyperploid karyotypes and large-scale chromosome alterations, which might be promising biomarkers correlated with tumor metastasis and chemoresistance.
Ming Du, Shuo Zhang, Xiaoxia Liu, Congjian Xu, Xiaoyan Zhang   +4 more
doaj   +1 more source

Autophagy-deficient breast cancer shows early tumor recurrence and escape from dormancy [PDF]

, 2018
Breast cancer patients who initially respond to cancer therapies often succumb to distant recurrence of the disease. It is not clear why people with the same type of breast cancer respond to treatments differently; some escape from dormancy and relapse ...
Manjili, Masoud H.
core   +1 more source

TRAP5 Inhibition Targeting Scar‐Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition

Advanced Science, EarlyView.
This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang, Yaodong Gu, Wen Du, Lin Xie, Jinwei Quan, Yu Zhao, Ye Cheng, Zhaonan Wei, Yuanyuan Sha, Yi Wang, Dechao Xu, Xiang Gao, Min Chen, Xiangchen Gu   +13 more
wiley   +1 more source

Full-Length Transcriptome Reveals Heterologous Sperm Fragments in Natural Gynogenetic Grass Carp

Fishes
Grass carp (Ctenopharyngodon idella) is one of the most economically important cyprinid species cultured in China. The diploid gynogenetic grass carp (2nGGC, 2n = 48) was generated from the hybrid of female grass carp (GC, 2n = 48) and male topmouth ...
Lang Qin, Yuxiang Wang, Ming Wen, Jinhui Huang, Xu Huang, Qian Chen, Dan Peng, Yang Wu, Qianye Wei, Fangzhou Hu, Kaijun Gong, Chun Zhang, Qinbo Qin, Chang Wu, Shaojun Liu   +14 more
doaj   +1 more source

Transcriptomic Drivers of Differentiation, Maturation, and Polyploidy in Human Extravillous Trophoblast

Frontiers in Cell and Developmental Biology, 2021
During pregnancy, conceptus-derived extravillous trophoblast (EVT) invades the endomyometrium, anchors the placenta to the maternal uterus, and remodels the spiral arteries in order to establish maternal blood supply to the fetoplacental unit.
Robert Morey, Robert Morey, Robert Morey, Omar Farah, Omar Farah, Sampada Kallol, Sampada Kallol, Daniela F. Requena, Daniela F. Requena, Morgan Meads, Morgan Meads, Matteo Moretto-Zita, Matteo Moretto-Zita, Francesca Soncin, Francesca Soncin, Louise C. Laurent, Louise C. Laurent, Mana M. Parast, Mana M. Parast   +18 more
doaj   +1 more source

Small RNAs regulation and genomic harmony: insights into allopolyploid evolution in marsh orchids (Dactylorhiza). [PDF]

New Phytol
Summary Hybridization and polyploidy are major drivers of plant diversification, often accompanied by shifts in gene expression and genome composition. Small RNAs (smRNAs) are thought to influence such genomic changes, particularly through their interactions with transposable elements (TEs).
Eriksson MC, Thornton M, Trucchi E, Wolfe TM, Balao F, Hedrén M, Paun O.   +6 more
europepmc   +2 more sources

Hybridization, polyploidy, and evolutionary transitions between monoecy and dioecy in Bryonia (Cucurbitaceae) [PDF]

, 2008
Correns’s 1903 (Berichte der Deutschen Botanischen Gesellschaft 21: 133 – 147) crosses between a monoecious and a dioecious species of Bryonia revealed the simple Mendelian inheritance of dioecy and provided the first instance of an XY sex determination ...
Renner, Susanne S., Volz, Stefanie M.
core   +1 more source

ZSL Orchestrates Synaptonemal Complex Assembly as a Central Region Scaffold to Ensure Synapsis Fidelity and Crossover Control in Polyploid Meiosis

Advanced Science, EarlyView.
A central molecular adaptor, ZSL, is identified that links transverse filaments ZYP1 to central element SCEP1/2 to drive synaptonemal complex assembly in Brassica napus. Loss of ZSL abolishes synaptonemal complex formation, disrupts meiotic chromosome segregation, and markedly increases crossovers, providing mechanistic insight into meiotic fidelity ...
Miaowei Geng, Shaochen Jia, Fei Cao, Cuiping Liu, Heshuang Zhang, Gang Xu, Jixin Zhuang, Yashi Zhang, Can Liu, Yuhang Zhao, Zilin Guo, Xinjie Yuan, Jiaqing Yang, Lei Chu, Bowei Cai, Hu Zhao, Chao Yang   +16 more
wiley   +1 more source