Results 131 to 140 of about 28,096 (159)

[Transformation of serum immunoglobulins to polyreactive antibodies].

Ukrainskii biokhimicheskii zhurnal (1978), 1998
In order to elucidate the mechanism of induction of serum immunoglobulins polyreactive properties by chaotropic ions, gel-chromatography of immunoglobulins in the medium containing 3.3 M KSCN, has been done. It was found that the transformation of serum immunoglobulins to polyreactive antibodies, which could react with different serological unrelated ...
S A, Bobrovnik, Iu I, Petrova, K A, Efetov   +2 more
openaire   +1 more source

Response: Gastric MALT Lymphoma–Derived Tumor Immunoglobulins Are Polyreactive and Respond to a Variety of Self and Foreign Antigens

Blood, 2010
Multiple attempts have been made in the past 2 decades to delineate the antigen specificity of tumor immunoglobulins expressed by mucosa-associated lymphoid tissue (MALT) lymphoma. These studies have produced rather discrepant results, which may be attributable to the different approaches to tumor-
Anne Müller, Vanessa J Craig
exaly   +3 more sources

[Ligand-induced structuring of polyreactive immunoglobulins].

Ukrains'kyi biokhimichnyi zhurnal (1999 ), 2004
The influence of several hydrophobic compounds with different structures on the binding of native and chaotropically modified bovine immunoglobulins to native and denatured nonspecific protein immobilized on the surface is researched. It is shown that the character of binding depends on the amount and mutual location of hydrophobic nuclei in the ...
L V, Il'ina, S V, Verevka
openaire   +1 more source

Polyreactive Transformation of Class G Immunoglobulins as a Vector for Search of Potential Means for Improving the Activity of Anti-endotoxin Immunity

Human Physiology, 2020
Short-term in vitro exposure of a chaotropic reagent to native class G immunoglobulins can significantly increase the activity of anti-endotoxin immunity and cause a decrease in the ability of effector cells for enterobacteria lipopolysaccharides (LPS). This leads to reducing the LPS-dependent activation of these cells and subsequent inflammation. This
A. I. Gordienko, N. V. Khimich, V. A. Beloglazov, A. V. Kubyshkin, M. Yu. Yakovlev   +4 more
openaire   +1 more source

The urodele amphibian Pleurodeles waltl has a diverse repertoire of immunoglobulin heavy chains with polyreactive and species-specific features

Developmental & Comparative Immunology, 2015
Urodele amphibians are an interesting model because although they possess the cardinal elements of the vertebrate immune system, their immune response is apparently subdued. This phenomenon, sometimes regarded as a state of immunodeficiency, has been attributed by some authors to limited antibody diversity.
Coralie, Fonte, Arnaud, Gruez, Stéphanie, Ghislin, Jean-Pol, Frippiat   +3 more
openaire   +2 more sources

[Transformation of serum immunoglobulins and monoclonal antibodies into polyreactive immunoglobulins].

Ukrainskii biokhimicheskii zhurnal (1978), 1998
It was shown that polyreactive properties of natural serum immunoglobulins or some monoclonal antibodies (i.e. their ability of binding to various antigenically dissimilar antigens) can be induced by the treatment with chaotropic ions (3.5 M KSCN, 5-30 min at 20 (C).
openaire   +1 more source

[Complement-binding and immuno-modulating properties of polyreactive immunoglobulins].

Ukrains'kyi biokhimichnyi zhurnal (1999 ), 2004
New data concerning biological properties of polyreactive immunoglobulins (PRIG) were obtained as a result of treatment of mouse serum immunoglobulins by 4 M KSCN and are presented in the paper. In particular, the capacity of PRIG to bind C1q, the subunit of the first component of complement was studied. It was shown that PRIG's binding capacity to C1q
S A, Bobrovnik, K A, Efetov, Iu I, Petrova, S V, Komisarenko   +3 more
openaire   +1 more source

[Transformation of specific antibodies to polyreactive immunoglobulins and their binding to blood vessel walls].

Ukrains'kyi biokhimichnyi zhurnal (1999 ), 2003
It was shown that 30-50% ethanol or 40-70% dimetilsulfoxide could efficiently induce in vitro transformation of specific monoclonal antibodies (mAbs) into non-specific polyreactive immunoglobulins (PRIG). Intravenous injection 0.4 ml of FeSO4-EDTA mixture (60 and 30 mkM respectively) could induce increase of PRIG reactivity in the blood-stream ...
openaire   +2 more sources

[Dynamics of the interaction of polyreactive immunoglobulins with immobilized antigens].

Ukrainskii biokhimicheskii zhurnal (1978), 1999
The kinetic of polyreactive immunoglobulins (PRIG) and immobilized antigen interaction was examined at different temperatures. It was shown that this process can be described by the so-called "competitive" model, and the relatively simple method for the rate constant determination for this process was developed.
openaire   +1 more source

[Mechanisms of interaction of polyreactive immunoglobulins and protein antigens].

Ukrains'kyi biokhimichnyi zhurnal (1999 ), 2002
New features of interaction between polyreactive immunoglobulins (PRIG) and protein antigens were considered. It was shown that unlike specific antibodies, recognizing mainly hydrophilic epitops of proteins and interacting against them with high affinity according to the mechanisms "lock-and-key" and/or "induced fit", PRIG recognized and ...
openaire   +1 more source