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[Complement-binding and immuno-modulating properties of polyreactive immunoglobulins].
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 2004New data concerning biological properties of polyreactive immunoglobulins (PRIG) were obtained as a result of treatment of mouse serum immunoglobulins by 4 M KSCN and are presented in the paper. In particular, the capacity of PRIG to bind C1q, the subunit of the first component of complement was studied. It was shown that PRIG's binding capacity to C1q
S A, Bobrovnik +3 more
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[Dynamics of the interaction of polyreactive immunoglobulins with immobilized antigens].
Ukrainskii biokhimicheskii zhurnal (1978), 1999The kinetic of polyreactive immunoglobulins (PRIG) and immobilized antigen interaction was examined at different temperatures. It was shown that this process can be described by the so-called "competitive" model, and the relatively simple method for the rate constant determination for this process was developed.
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Ukrains'kyi biokhimichnyi zhurnal (1999 ), 2003
It was shown that 30-50% ethanol or 40-70% dimetilsulfoxide could efficiently induce in vitro transformation of specific monoclonal antibodies (mAbs) into non-specific polyreactive immunoglobulins (PRIG). Intravenous injection 0.4 ml of FeSO4-EDTA mixture (60 and 30 mkM respectively) could induce increase of PRIG reactivity in the blood-stream ...
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It was shown that 30-50% ethanol or 40-70% dimetilsulfoxide could efficiently induce in vitro transformation of specific monoclonal antibodies (mAbs) into non-specific polyreactive immunoglobulins (PRIG). Intravenous injection 0.4 ml of FeSO4-EDTA mixture (60 and 30 mkM respectively) could induce increase of PRIG reactivity in the blood-stream ...
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[Mechanisms of interaction of polyreactive immunoglobulins and protein antigens].
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 2002New features of interaction between polyreactive immunoglobulins (PRIG) and protein antigens were considered. It was shown that unlike specific antibodies, recognizing mainly hydrophilic epitops of proteins and interacting against them with high affinity according to the mechanisms "lock-and-key" and/or "induced fit", PRIG recognized and ...
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[Mechanisms for increasing the activity of polyreactive immunoglobulins in vivo].
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 2000The mechanisms of increasing of polyreactive immunoglobulin (PRIG) activity in vivo are suggested. It was shown that at some conditions, which can be observed in organism in sites of inflammation, activity of serum PRIG could be enhance considerably. This enhancing might be induced either by reactive oxygen species, mainly by hydroxyl radicals, or by ...
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[Polyreactive immunoglobulins recognize hydrophobic parts of proteins].
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 2002It was shown that polyreactive immunoglobulins (PRIG), which are capable to interact non-specifically with various antigens, could differ from so called natural antibodies, which have also the capacity to react non-specifically with various antigens, including self-antigens.
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[Polyreactive immunoglobulins and natural antibodies are different substances].
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 2003It was shown that the polyreactive immunoglobulins of intact animal or human sera and the natural antibodies of these sera have different properties. Polyreactive immunoglobulins interact non-specifically with various antigens and this interaction is strongly dependent on an exposure of hydrophobic sites by antigens and, probably, by polyreactive ...
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[Relationship between polyreactive properties of immunoglobulins and level of lipids in them].
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 2001Presented paper deals with the relationship between immunoglobulin polyreactive properties and its lipid composition. Serum blood immunoglobulin fraction of an intact rabbit as an experimental model was used. Immunoglobulins (Ig) obtained by this way were transformed into polyreactive immunoglobulins (PRIg) by treatment with chaotropic agent KSCN or ...
S A, Bobrovnik +4 more
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[The effect of blood serum polyreactive immunoglobulins on serum antibody affinity determination].
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 2010The presence of polyreactive immunoglobulins in sera may substantially influence on the accuracy of antibody affinity determination. In order to obtain precise values of antibody affinity one should apply one of two following ways. First, one should block polyreactive immunoglobulins with high concentration of Twin 20 and high concentration of any ...
S A, Bobrovnik +2 more
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