Results 11 to 20 of about 1,741 (114)

Circ-PNPT1 contributes to gestational diabetes mellitus (GDM) by regulating the function of trophoblast cells through miR-889-3p/PAK1 axis

Diabetology & Metabolic Syndrome, 2021
Background Gestational diabetes mellitus (GDM) is the most common medical complication of pregnancy. CircRNA polyribonucleotide nucleotidyltransferase 1 (circ-PNPT1) has been found to be abnormally expressed in GDM patients.
Li Zhang, Ming Zeng, Fei Tang, Jun Chen, Dongmei Cao, Ze-nan Tang   +5 more
doaj   +1 more source

Additional routes to Staphylococcus aureus daptomycin resistance as revealed by comparative genome sequencing, transcriptional profiling, and phenotypic studies. [PDF]

PLoS ONE, 2013
Daptomycin is an extensively used anti-staphylococcal agent due to the rise in methicillin-resistant Staphylococcus aureus, but the mechanism(s) of resistance is poorly understood.
Yang Song, Aileen Rubio, Radheshyam K Jayaswal, Jared A Silverman, Brian J Wilkinson   +4 more
doaj   +1 more source

Downregulation of LRP/LR with siRNA inhibits several cancer hallmarks in lung cancer cells

FEBS Open Bio, Volume 13, Issue 2, Page 323-340, February 2023., 2023
LRP/LR is overexpressed in many cancer cell types and is associated with various cancer‐promoting processes. In this study, we downregulated LRP/LR in lung cancer cells and showed that this strategy has a four‐fold function in impeding key cancer hallmarks in the lung cancer cells, which therefore has the potential for improving the prognosis of those ...
Monique J. Bignoux, Tyrone C. Otgaar, Martin Bernert, Stefan F. T. Weiss, Eloise Ferreira   +4 more
wiley   +1 more source

Heterozygous PNPT1 Variants Cause Spinocerebellar Ataxia Type 25

Annals of Neurology, Volume 92, Issue 1, Page 122-137, July 2022., 2022
Objective Dominant spinocerebellar ataxias (SCA) are characterized by genetic heterogeneity. Some mapped and named loci remain without a causal gene identified. Here we applied next generation sequencing (NGS) to uncover the genetic etiology of the SCA25 locus.
Mathieu Barbier, Melanie Bahlo, Alessandra Pennisi, Maxime Jacoupy, Rick M. Tankard, Claire Ewenczyk, Kayli C. Davies, Patricia Lino‐Coulon, Claire Colace, Haloom Rafehi, Nicolas Auger, Brendan R. E. Ansell, Ivo van der Stelt, Katherine B. Howell, Marie Coutelier, David J. Amor, Emeline Mundwiller, Lena Guillot‐Noël, Elsdon Storey, R. J. McKinlay Gardner, Mathew J. Wallis, Alfredo Brusco, Olga Corti, Agnès Rötig, Richard J. Leventer, Alexis Brice, Martin B. Delatycki, Giovanni Stevanin, Paul J. Lockhart, Alexandra Durr   +29 more
wiley   +1 more source

Mitochondrial RNA processing defect caused by a SUPV3L1 mutation in two siblings with a novel neurodegenerative syndrome

Journal of Inherited Metabolic Disease, Volume 45, Issue 2, Page 292-307, March 2022., 2022
Abstract SUPV3L1 encodes a helicase that is mainly localized in the mitochondria. It has been shown in vitro to possess both double‐stranded RNA and DNA unwinding activity that is ATP‐dependent. Here we report the first two patients for this gene who presented with a homozygous preliminary stop codon resulting in a C‐terminal truncation of the SUPV3L1 ...
Selma L. van Esveld, Richard J. Rodenburg, Fathiya Al‐Murshedi, Eiman Al‐Ajmi, Sana Al‐Zuhaibi, Martijn A. Huynen, Johannes N. Spelbrink   +6 more
wiley   +1 more source

Comparative genomics provides structural and functional insights into Bacteroides RNA biology

Molecular Microbiology, Volume 117, Issue 1, Page 67-85, January 2022., 2022
Most of our knowledge of bacterial regulatory RNAs and their associated proteins stems from model organisms such as Escherichia coli and Salmonella enterica. In contrast, the RNA biology of Bacteroides spp.—an important component of the human gut microbiota—is significantly understudied.
Gianluca Prezza, Daniel Ryan, Gohar Mädler, Sarah Reichardt, Lars Barquist, Alexander J. Westermann   +5 more
wiley   +1 more source

The Mystery of Exosomes in Gestational Diabetes Mellitus

Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022
Gestational diabetes mellitus (GDM) is one of the common pregnancy complications, which increases the risk of short‐term and long‐term adverse consequences in both the mother and offspring. However, the pathophysiological mechanism of GDM is still poorly understood.
Tong Chen, Dan Liu, Demetrios Kouretas
wiley   +1 more source

Dissecting the phenotypic components and genetic architecture of maize stem vascular bundles using high‐throughput phenotypic analysis

Plant Biotechnology Journal, Volume 19, Issue 1, Page 35-50, January 2021., 2021
Summary High‐throughput phenotyping is increasingly becoming an important tool for rapid advancement of genetic gain in breeding programmes. Manual phenotyping of vascular bundles is tedious and time‐consuming, which lags behind the rapid development of functional genomics in maize.
Ying Zhang, Jinglu Wang, Jianjun Du, Yanxin Zhao, Xianju Lu, Weiliang Wen, Shenghao Gu, Jiangchuan Fan, Chuanyu Wang, Sheng Wu, Yongjian Wang, Shengjin Liao, Chunjiang Zhao, Xinyu Guo   +13 more
wiley   +1 more source

A eubacterial origin for the human tRNA nucleotidyltransferase? [PDF]

, 2001
tRNA CCA-termini are generated and maintained by tRNA nucleotidyltransferases. Together with poly(A) polymerases and other enzymes they belong to the nucleotidyltransferase superfamily.
Mörl, M. ; https://orcid.org/, Mörl, Mario, Reichert, Andreas S., Thurlow, D., A.S. Reichert, M. Mörl, Reichert, A., Thurlow, D. L., Reichert, A. S., Mörl, M., D.L. Thurlow   +10 more
core   +1 more source

Thermodynamic investigation of the helix-coil transitions of a polyribonucleotide system [PDF]

, 1969
Neumann E, Ackermann T. Thermodynamic investigation of the helix-coil transitions of a polyribonucleotide system. Journal of Physical Chemistry.
Ackermann, Theodor, Neumann, Eberhard
core   +1 more source