Results 91 to 100 of about 291,495 (261)

Purification of Disassembled Capsid Protein by Hydroxyapatite Chromatography Enhances Virus‐Like Particle Recovery

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Virus‐like particles (VLPs) are a promising modality with extensive applications in prophylactic and therapeutic vaccine design. Human Papillomavirus (HPV) vaccines are one such example where VLP vaccine applications have led to the successful reduction in HPV‐associated diseases, such as cervical cancer.
Nicholas Samuelson, Nathaniel Parker, Shiyi Wang, Sara Daley, Aaron Cote, Michael A. Winters   +5 more
wiley   +1 more source

Changes in serogroup and genotype prevalence among carried meningococci in the United Kingdom during vaccine implementation [PDF]

, 2011
Natural fluctuations in carried meningococcal genotypes and phenotypes a can be affected by the use of conjugate vaccines, and not all of these changes are anticipatable in advance of vaccine ...
McCarthy, Noel D., Maclennan, Jenny, Evans, Meirion R, Rachel Urwin, Cameron, J. Claire, Neal, Keith R, Ibarz-Pavón, AB, Nicholas J. Andrews, Stuart C. Clarke, Cann, Kathryn, Maiden, MC, Noel D. McCarthy, Cameron, JC, Evans, MR, Maiden, Martin, James M. Stuart, Harrison, S, Ala'aldeen, Dlawer, Cunningham, Richard, Martin C. J. Maiden, Jolley, Keith A, Derrick W. Crook, Dlawer Ala'Aldeen, Walker, AM, Baxter, David, Gray, Stephen J., Urwin, R, Crook, Derrick W., Keith R. Neal, Clarke, SC, Clarke, Stuart C, Maiden, Martin C. J., Jolley, Keith A., Stuart, James M., Maiden, Martin CJ, Maclennan, J, Keith A. Jolley, Kaczmarski, E, Walker, A. Mark, J. Simon Kroll, Richard Cunningham, Andrews, NJ, J. Claire Cameron, Crook, DW, Evans, Meirion Rhys, Harrison, Sarah, Andrews, Nicholas J, Ala'aldeen, D, Edward Kaczmarski, Baxter, D, McCarthy, Noel D, Cann, K, Crook, Derrick W, Kathryn Cann, Ibarz-Pavón, Ana Belén, Clarke, Stuart C., Evans, Meirion R., A. Mark Walker, Cunningham, R, Kroll, J. Simon, Kroll, J Simon, Neal, KR, Cameron, J Claire, Maiden, MCJ, Andrews, Nicholas J., Neal, Keith R., McCarthy, ND, Stephen J. Gray, Jenny MacLennan, Meirion R. Evans, Crook, Derrick, Urwin, Rachel, Stuart, James M, Stuart, JM, Sarah Harrison, Gray, SJ, Gray, Stephen J, Ana Belén Ibarz-Pavón, Walker, A Mark, Kaczmarski, Edward, David Baxter, Andrews, Nicholas J., Kroll, JS, Jolley, KA   +83 more
core   +1 more source

Advanced nanotherapeutics for combating ocular infections: Rational design, antimicrobial mechanisms, and therapeutic breakthroughs

BMEMat, EarlyView.
Nanomaterials revolutionize ocular infection treatment by enabling targeted drug delivery and enhanced antimicrobial efficacy against resistant pathogens. This review systematically explores their rational design, multimodal mechanisms, and translational potential for next‐generation anti‐infective therapies.
Yujia Liu, Xuetian Wen, Yue Tan, Rui Zeng, Yijuan Zhang, Tong Lin, Lan Gong, Zichao Luo   +7 more
wiley   +1 more source

From pathogen to “living drug factory” innovative strategies and clinical translation of bacteria as programmable intelligent vectors for cancer therapy

BMEMat, EarlyView.
Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen, Weichen Zhang, Gaoli Niu, Li Wang, Ruiyan Li, Yueyue Fan, Feixue Lu, Lingling Xu, Xiaoyuan Ji, Yong Kang   +9 more
wiley   +1 more source

Screening of bacterial molecules with antagonistic or adjuvant activity [PDF]

, 2010
The Lipopolysaccharides (LPSs) are the major constituents of the outer membrane of Gram-negative bacteria and the interest in their chemical characterization is motivated by the close correlation existing between the structure and the biological activity
Fregolino, Eleonora
core   +1 more source

The Seroepidemiology of Haemophilus influenzae Type B Prior to Introduction of an Immunization Programme in Kathmandu, Nepal. [PDF]

, 2014
Haemophilus influenzae type b (Hib) is now recognized as an important pathogen in Asia. To evaluate disease susceptibility, and as a marker of Hib transmission before routine immunization was introduced in Kathmandu, 71 participants aged 7 months-77 ...
Neelam Adhikari, Thorson, SM, Clutterbuck, EA, Marshall, AS, Gautam Samir C., Adhikari, N, Shrestha, S, Barker, CI, Andrew J. Pollard (44971), Shrestha Shrijana, Barker Charlotte I. S., Pollard Andrew J., Kelly Dominic F., Elizabeth A Clutterbuck, Dominic F. Kelly (301751), Samir C Gautam, Adhikari Neelam, Charlotte I S Barker, Clutterbuck Elizabeth A., Pulickal Anoop S., Shrijana Shrestha, Kibwana, E, Dominic F Kelly, Andrew J Pollard, Marshall Andrew S. J., Pulickal, AS, Gautam, SC, Andrew S J Marshall, Anoop S. Pulickal (512430), Anoop S Pulickal, Thorson Stephen M., Charlotte I. S. Barker (512429), Samir C. Gautam (301746), Kibwana Elizabeth, Stephen M Thorson, Elizabeth Kibwana (512431), Kelly, DF, Stephen M. Thorson (512433), Pollard, AJ, Neelam Adhikari (301753), Pollard, Andrew, Elizabeth Kibwana, Andrew S. J. Marshall (512428), Shrijana Shrestha (512434), Elizabeth A. Clutterbuck (512432)   +44 more
core   +2 more sources

Beyond antimicrobials: Ecological nano‐strategies for rebalancing dysbiotic oral microbial homeostasis

BMEMat, EarlyView.
Oral microbial homeostasis, a dynamic host‐microbe balance, is vital in infectious diseases. Conventional antibiotics often disrupt this homeostasis, spurring interest in nanomaterials for oral microbial homeostasis rebalancing. This review outlines nanomaterial strategies across three ecological levels (population/community, ecosystem, and cross ...
Chen Hu, Aohan Luan, Yujun Yang, Linlin Wang, Huilin Wang, Ning Wang, Guixin He, Yajie Yang, Rabiya Noor, Jawad Hussain, Longquan Shao   +10 more
wiley   +1 more source

In‐line Raman spectroscopy real‐time glucose prediction method for commercial pneumococcal vaccine drug substance fermentation manufacturing process control

Biotechnology Progress, EarlyView.
Abstract Traditional off‐line analysis methods to quantify residual metabolite concentrations in a drug substance fermentation process consume valuable time, require costly resources, and demand potentially hazardous manual operations when working with pathogenic biological organisms.
Griffin P. Thomas, Brian C. Marks, Barbara B. Alvarado‐Hernandez, Matthew Woodling, James O'Connor, Roberto Ortiz, John Higgins, Jon Shanter   +7 more
wiley   +1 more source

Determination of the binding affinities of Neisseria meningitidis serogroup W capsule polymerase with two nucleotide sugar substrates

BMC Research Notes, 2018
Objective Meningococcal meningitis is a public health burden. Immunization strategies have reduced global incidence of the disease. Glycoconjugate vaccines are the most effective type of vaccine to combat most causes of meningococcal meningitis.
Abeer Sharyan, Cendy Gonzalez, Ophelia Ukaegbu, Kayla Powell, Pumtiwitt C. McCarthy   +4 more
doaj   +1 more source

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source