Results 301 to 310 of about 786,143 (326)
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Annals of Internal Medicine, 1986
Overwhelming sepsis is a serious complication of staging splenectomy in Hodgkin's disease. To define an optimal immunization strategy, 51 patients received 14-valent pneumococcal, Haemophilus influenzae type b, and meningococcal group C vaccines before ...
G. Siber +4 more
semanticscholar +1 more source
Overwhelming sepsis is a serious complication of staging splenectomy in Hodgkin's disease. To define an optimal immunization strategy, 51 patients received 14-valent pneumococcal, Haemophilus influenzae type b, and meningococcal group C vaccines before ...
G. Siber +4 more
semanticscholar +1 more source
The Pediatric Infectious Disease Journal, 1987
The purpose of this study was to evaluate differences in the safety and immunogenicity of Haemophilus influenzae type b (Hib) capsular polysaccharide vaccine produced by two manufacturers (Connaught and Praxis) in children 18 and 24 months of age. Eighty-
D. Greenberg +5 more
semanticscholar +1 more source
The purpose of this study was to evaluate differences in the safety and immunogenicity of Haemophilus influenzae type b (Hib) capsular polysaccharide vaccine produced by two manufacturers (Connaught and Praxis) in children 18 and 24 months of age. Eighty-
D. Greenberg +5 more
semanticscholar +1 more source
Capsular Polysaccharides as Vaccine Candidates
1990The discovery of a “specific soluble substance” secreted by pneumococci during growth (Dochez and Avery 1917) and the identification of this substance as a carbohydrate (Heidelberger and Avery 1923) were new and important developments in vaccine technology.
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Polysaccharide–Protein Conjugate Vaccines
2011It is to Karl Landsteiner that we owe the notion that the immunologic properties of nonimmunogenic ligands (haptens), including saccharides, can be improved by covalent attachment to proteins [1]. His pioneering studies in the 1920s influenced Walter Goebel and Oswald Avery (his colleague at the Rockefeller Institute, NY) who sought evidence that serum
John B. Robbins +3 more
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Chemically Modified Capsular Polysaccharides as Vaccines
1988Capsular polysaccharides have assumed an important role as vaccines against disease caused by bacteria in humans. The concept of using pure definable polysaccharides devoid of their accompanying complex bacterial mass is technically elegant and is obviously capable of extension into other areas of immunoprophylaxis.
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Potential and limitations of polysaccharide vaccines in infancy
Vaccine, 1998Of infections caused by encapsulated bacteria, those due to Haemophilus influenzae b (Hib) are among the most restricted to infancy and require very early immunisation. Hib capsular polysaccharide (CPS) has the most typical T-cell independent profile. The absence of efficacy of this vaccine in infants triggered development of conjugate vaccines which ...
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Polysaccharide Meningococcal Vaccines—Current Status
Hospital Practice, 1979Two separate periods of intensive research, with a 25-year hiatus after the advent of the sulfonamides, have resulted in two good, but imperfect, antimeningococcal vaccines--against serogroups A and C. Neither is recommended for routine use, but both have been effective in halting epidemics.
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The Immunobiology of Polysaccharide and Conjugate Vaccines
2014Infections with polysaccharide (PS)-encapsulated extracellular bacteria are a major source of global morbidity and mortality among infants, as well as the elderly and immunosuppressed individuals. An understanding of the immunological basis of glycoconjugate interactions is still emerging but is already helping shape strategies to improve conjugate ...
Clifford M. Snapper +2 more
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Polysaccharide Vaccines: Determinants of Clinical Efficacy
Hospital Practice, 1997Many common bacteria cause disease because their polysaccharide capsules prevent phagocytosis. Antibody directed against these capsules is the basis for some of the most effective bacterial vaccines. Nevertheless, many diseases caused by such bacteria continue to cause serious morbidity.
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Immunogenicity and Vaccines of Polysaccharides
2021Benjamin Obukowho Emikpe +1 more
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