Results 51 to 60 of about 87,635 (197)

3D Printing of Bacteriophage‐Loaded Hydrogels: Development of a Local and Long‐Lasting Delivery System

Advanced Healthcare Materials, EarlyView.
This research investigates the feasibility of 3D‐printing of a bacteriophage‐containing hydrogel made of alginate and methylcellulose. The printed hydrogels steadily release active bacteriophages for up to 35 days which is beneficial to treat implant‐associated infections.
Corina Vater, Gopala Krishna Mannala, Max von Witzleben, Richard Frank Richter, Nike Walter, Michael Gelinsky, Volker Alt, Anja Lode, Markus Rupp   +8 more
wiley   +1 more source

Marine Algae Polysaccharides - a Promising Means of Pathogenetic Therapy of Infectious Diarrhea

Антибиотики и Химиотерапия, 2020
The review considers the current views on pathogenesis and therapeutic targets in infectious diarrhea that develops as a result of exposure of enterocytes to viruses or bacterial toxins. The main methods of infectious diarrhea treatment and disadvantages
N. N. Besednova, T. A. Kuznetsova, T. S. Zaporozhets, S. P. Kryzhanovsky, L. G. Gusevа, T. N. Zvyagintseva   +5 more
doaj   +1 more source

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Biofilm Inhibition: Compounds with Antibacterial Effects

Journal of Interdisciplinary Medicine, 2018
Biofilms can form on living or inert surfaces and prevail in natural, industrial, and hospital environments. They are made of bacteria organized in a coordinated functional community.
Feier Andrei-Marian, Ioanovici Andrei-Constantin, Ionescu Radu-Cristian, Toth Tamas, Russu Octav-Marius   +4 more
doaj   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Selective utilization of medicinal polysaccharides by human gut Bacteroides and Parabacteroides species

Nature Communications
Human gut Bacteroides and Parabacteroides species play crucial roles in human health and are known for their capacity to utilize diverse polysaccharides.
Zepeng Qu, Hongbin Liu, Ji Yang, Linggang Zheng, Jumin Huang, Ziming Wang, Chun Xie, Wenlong Zuo, Xiong Xia, Lin Sun, Yifa Zhou, Ying Xie, Jingguang Lu, Yizhun Zhu, Lili Yu, Lihua Liu, Hua Zhou, Lei Dai, Elaine Lai-Han Leung   +18 more
doaj   +1 more source

Protection against N. gonorrhoeae induced by OMV-based meningococcal vaccines are associated with cross-species directed humoral and cellular immune responses

Frontiers in Immunology
IntroductionLimited protective immunologic responses to natural N. gonorrhoeae infection and a lack of knowledge about mechanisms of protection have hampered development of an effective vaccine.
Weiyan Zhu, Andreea Waltmann, Marguerite B. Little, Kristie L. Connolly, Kathryn A. Matthias, Keena S. Thomas, Mary C. Gray, Aleksandra E. Sikora, Aleksandra E. Sikora, Alison K. Criss, Margaret C. Bash, Andrew N. Macintyre, Ann E. Jerse, Joseph A. Duncan, Joseph A. Duncan   +14 more
doaj   +1 more source

Stimulation de la fermentation malolactique par l'addition au vin d'enveloppes cellulaires de levure et différents adjuvants de nature polysaccharidique et azotée

OENO One, 1985
L'addition au vin d'écorces de levure (0,2 g par litre) permet une stimulation de la fermentation malolactique. Leur action s'exerce en augmentant la population bactérienne et surtout en retardant et atténuant la phase de déclin. Le traitement du vin par
Aline Lonvaud-Funel, Catherine Desens, Annick Joyeux   +2 more
doaj   +1 more source

Medical Fabrics with Non‐Antibiotic, Supramolecular Antimicrobial Coatings: A Preventive Approach to Combat Biofilm Formation and Bacterial Dissemination

Advanced Healthcare Materials, EarlyView.
The study presents an antibiotic‐free strategy using medical fabrics coated with supramolecular assemblies of polyarginine and hyaluronic acid. These coatings showed strong antimicrobial and anti‐biofilm activity in vitro and in vivo, achieving major bacterial load reductions, including against MRSA.
Adjara Diarrassouba, Abdessalem Rekiki, Cécile Loubière, Sabine Kuchler‐Bopp, Lauriane Petit, Cynthia Calligaro, Derry Mercer, Aurore Gaudin, Naomi Canourgues, Emilie Adicéam, Benoit Beitz, Jeremy Welsch, Annabelle Vigué, Markus j. Kettel, Michael Karl, Chloé Guilbaud‐Chéreau, Philippe Lavalle, Nihal Engin Vrana, Skander Hathroubi   +18 more
wiley   +1 more source