Results 191 to 200 of about 17,352 (237)

Olfml3 Regulates Microglial Inflammation and Neuronal Injury in Obstructive Sleep Apnea via Cybb‐Mediated TLR4/NF‐κB Pathway

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
In obstructive sleep apnea (OSA), intermittent hypoxia (IH) induces downregulation of Olfml3 in microglial cells and inhibits the activation of microglial cells; Low Olfml3 expression leads to increased expression of the downstream gene Cybb; Cybb activates the TLR4/NF‐κB inflammatory pathway, driving microglial M1 polarization and the release of ...
Deqiu Kong, Yaowen Wang, Xianjun Chen, Cihao Hu, Bin Zhang, Xing Chen   +5 more
wiley   +1 more source

Cardiorenal Outcomes of Dapagliflozin vs. Empagliflozin in Advanced Chronic Kidney Disease and Diabetes

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 168-177, July 2026.
Target trial emulation of a multi‐institutional electronic health record network showed comparable cardiorenal effectiveness and safety of dapagliflozin versus empagliflozin in adults with type 2 diabetes and advanced‐stage chronic kidney disease.
Shih‐Hsuan Lin, Jia‐Jin Chen, Ching‐Chung Hsiao, Yu‐Wei Fang, Meng‐Ting Chen, Ming‐Hsien Tsai, Huang‐Yu Yang   +6 more
wiley   +1 more source

UNITED: A Unified Transparent and Efficient Phase I/II Trial Design for Dose Optimization Accounting for Ordinal Graded, Continuous and Mixed Toxicity and Efficacy Endpoints. [PDF]

Stat Med
Li M, Guo Z, Qiu Y.
europepmc   +1 more source

Bridging Theory and Prediction: A Hybrid SEM and Machine Learning Approach to Optimize Lean Construction for Megaproject Sustainability in China

Corporate Social Responsibility and Environmental Management, Volume 33, Issue 4, Page 5017-5039, July 2026.
ABSTRACT Construction megaprojects, large‐scale, complex, and capital‐intensive, are particularly prone to inefficiencies, cost overruns, delays, and environmental degradation due to fragmented workflows, stakeholder misalignment, and resource intensity.
Abdelazim Ibrahim, Tarek Zayed, Zoubeir Lafhaj, Ahmed Maged, Ahmed Farouk Kineber, Jingchao Yang   +5 more
wiley   +1 more source

Comb-BOIN12: A Utility-Based Bayesian Optimal Interval Design for Dose Optimization in Cancer Drug-Combination Trials. [PDF]

Stat Biopharm Res
Lu M, Zhang J, Yuan Y, Lin R.
europepmc   +1 more source

Habitat Heterogeneity Drives Niche Partitioning and Morphological Divergence in Two Parapatric Diploderma Lizard Species

Ecology and Evolution, Volume 16, Issue 7, July 2026.
This study focused on two closely related parapatric species, Diploderma yangi and D. slowinskii, which occupy contrasting microhabitats across the Nujiang River Basin in western China. The analysis integrated environmental, morphological, and dietary datasets to elucidate how niche partitioning stabilizes species boundaries in a landscape ...
Yuhao Wen, Songwen Tan, Yihua Xiang, Wei Gao, Peng Guo, Bingjun Dong, Yayong Wu   +6 more
wiley   +1 more source

A practical guide to species trend detection with unstructured data using local frequency scaling (Frescalo)

Ecography, Volume 2026, Issue 7, July 2026.
Accurately measuring biodiversity change remains a central challenge in ecology. Beyond the general idea of quantifying temporal species frequency changes, several sampling‐related biases in data collection remain key methodological challenges to consider. Long‐term standardized ecological data are rare, and most available datasets exhibit considerable
Romain Goury, Diana E. Bowler, Colin Harrower, Tamara Münkemüller, Jeanne Vallet, Jon M. Yearsley, Wilfried Thuiller, Oliver L. Pescott   +7 more
wiley   +1 more source

A phase 1b study of the ERK inhibitor MK-8353 plus pembrolizumab in patients with advanced solid tumors. [PDF]

Invest New Drugs
Lakhani NJ, Burris H, Miller WH, Huang M, Chen LC, Siu LL.   +5 more
europepmc   +1 more source

A Comparative Study of IVIM‐MRI Fitting Techniques in Glioma Grading: Conventional, Bayesian, and Voxel‐Wise and Spatially‐Aware Deep Learning Approaches

Journal of Magnetic Resonance Imaging, Volume 64, Issue 1, Page 184-200, July 2026.
ABSTRACT Background Intravoxel incoherent motion (IVIM) analysis of diffusion‐weighted MRI (DWI) provides microvascular perfusion and diffusion information. However, parameter estimation is limited by noise sensitivity, variability across fitting methods, and lack of standardization.
Misha P. T. Kaandorp, Andras Jakab, Christian Federau, Peter T. While   +3 more
wiley   +1 more source

Is AI an Algorithm by Any Other Name? Behavioral Reactions to AI‐ and Model‐Based Demand Planning Algorithms

Journal of Operations Management, Volume 72, Issue 5, Page 656-675, July 2026.
ABSTRACT With the ongoing deployment of AI algorithms, managers do not know whether existing demand planning processes account for possible differences in human behavior when using AI‐based systems in comparison to legacy model‐based systems. This study examines how human behavior may differ when performing demand forecasting tasks due to the ...
Finnegan McKinley, Rebekah Brau, John Aloysius, Adriana Rossiter Hofer   +3 more
wiley   +1 more source