Results 71 to 80 of about 823,086 (268)

Archaeological and numismatical findings from the vicinitie of Bolshiye Atrjasi village (Tetjushy district of Tatarstan Republic)

Поволжская археология, 2015
The objects found at Big Atrjasi village in the Tetjushy district of Tatarstan is considered in article. The village is known by the unique cemetery with stone gravestones of 1314 – 1323.
Rudenko Konstantin A., Bugarchev Aleksey I.   +1 more
doaj  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Regional Copula Modeling of Rainfall Duration and Intensity: Derivation and Validation of IDF Curves in the Kastoria Basin

Hydrology
Intensity–Duration–Frequency (IDF) curves are the cornerstone of hydraulic infrastructure design, yet standard methodologies often fail to account for the complex dependence structure of rainfall characteristics and the non-stationary effects of climate ...
Evangelos Leivadiotis, Aris Psilovikos, Silvia Kohnová   +2 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The infinity pool

Nature Physics, 2015
5 pages, 1 figure, submitted for ...
openaire   +2 more sources

Regularized Pooling

, 2020
12 pages, 10 figures, accepted for ICANN ...
Takato Otsuzuki, Hideaki Hayashi, Yuchen Zheng 0001, Seiichi Uchida   +3 more
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

ANALYSIS OF APPROACHES TO THE DEVELOPMENT OF SPORTS MEDICINE SERVICES AND MEDICAL SUPPORT IN MASS SPORT AND ELITE SPORT

Актуальные проблемы теоретической и клинической медицины
Relevance. The growth of mass and professional sports increases the participants’ workloads and the risk of injury, underscoring the need for effective medical support systems. Modern sports medicine has developed as an interdisciplinary field, combining
R. N. Sapargaliyev, S. E. Muzrapova, R. A. Sembayeva   +2 more
doaj   +1 more source

Modeling of the corium jet penetration into the pool of volatile coolant under reactor vessel [PDF]

Ядерна фізика та енергетика, 2010
Developed mathematical model and some results of its application to the element of the passive protection system against severe accidents at NPP with water pool under reactor vessel for corium melt and particles’ cooling are presented.
V. H. Moghaddam, I. V. Kazachkov
doaj