Results 151 to 160 of about 1,164,954 (301)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Retraction Note: Analysis of the factors influencing moderate to poor performance status in patients with cancer after chemotherapy: a cross-sectional study comparing three models. [PDF]

Sci Rep
Xi K, Jingping L, Yaqing L, Xinyuan Y, Hui L, Mei Y, Qingyue C, Dun L.   +7 more
europepmc   +1 more source

Pouring some water into the wine-Poor performance of endoscopists in artificial intelligence studies. [PDF]

United European Gastroenterol J, 2022
Weigt J.
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

A Novel Approach for Stereotactic Radiosurgery of Multiple Brain Metastasis in a Patient With Poor Performance Status: A Case Report. [PDF]

Case Rep Oncol Med
Iranmehr A, Sheikholeslami S, Banaee N, Shirani M, Farzin M, Jafari F.   +5 more
europepmc   +1 more source

Active Trading and (Poor) Performance

, 2019
Individuals often invest actively and generate inferior returns. Social interactions might exacerbate this tendency, but the causal effect from peer effects on active trading are difficult to identify empirically. This paper exploits the exogenous assignment of students to classrooms in a large-scale financial education initiative to evaluate the ...
Escobar, Laura, Pedraza, Alvaro
openaire   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Investigating factors contributing to poor performance in teaching and learning of N3 assembly drawing : a case of uMgungundlovu TVET college

Poor performance in Assembly Drawing (AD) has been a significant issue in Engineering Graphics and Design (EGD) in high schools and TVET colleges. This poor performance in AD, which is a crucial component of the EGD exam, leads to students not performing
Mkhwanazi, Mthokozisi Sakhile, Mlambo, Philani Brian   +1 more
core   +1 more source

Evaluation of fitness parameters in relation to racing results in 245 Standardbred trotter horses submitted for poor performance examination: A retrospective study. [PDF]

PLoS One, 2023
Lo Feudo CM, Stucchi L, Stancari G, Conturba B, Bozzola C, Zucca E, Ferrucci F.   +6 more
europepmc   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source