Results 51 to 60 of about 1,164,954 (301)

Tolerance of weekly metronomic paclitaxel and carboplatin as neoadjuvant chemotherapy in advanced ovarian cancer patients who are unlikely to tolerate 3 weekly paclitaxel and carboplatin

open access: yesSouth Asian Journal of Cancer, 2016
Objective: There are little data regarding safety and effectiveness of neoadjuvant chemotherapy (NACT) in patients who are considered unfit for receiving 3 weekly paclitaxel and carboplatin.
S B Dessai   +7 more
doaj   +1 more source

Poor performer

open access: yes, 2023
\(\bf Introduction:\) Several factors are known to influence speech perception in cochlear implant (CI) users. To date, the underlying mechanisms have not yet been fully clarified. Although many CI users achieve a high level of speech perception, a small percentage of patients does not or only slightly benefit from the CI (poor performer, PP).
Völter, Christiane (Prof. Dr. med.)   +5 more
openaire   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

EXPLORING TEACHER AND LEARNER PERSPECTIVES ON POOR PERFORMANCE IN SETSWANA HOME LANGUAGE IN MULTILINGUAL CLASSROOMS

open access: yesJournal of South African Democratic Teachers Union
The study aims to improve negative perspectives that affect performance in the Setswana home language in multilingual classrooms, and the study employed the interpretivist research paradigm, which enhances comprehension of social phenomena and human ...
Selina Malebo   +2 more
doaj   +1 more source

UNINTENDED NEGATIVE EFFECTS OF CLIENT PROJECT COST CONTROLS: A SYSTEM DYNAMICS APPROACH

open access: yesSouth African Journal of Industrial Engineering, 2018
Project controls have been defined in the existing literature as managerial decisions and actions aimed at rectifying poor project performance. Understanding the potential unintended negative effects of such controls will be beneficial to project ...
Chitongo, Alfred Mutizwa   +1 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

The lack of parent involvement as hindrance in selected public primary schools in South Africa: The voices of educators

open access: yesPerspectives in Education, 2018
Although parent involvement is fundamental for school functioning, the nature and extent of such involvement is debatable and contested amongst stakeholders.
Paul Nwati Munje, Vusi Mncube
doaj   +3 more sources

Poor Performance and techniques for comparing individual productivity

open access: yesLabour & Law Issues
This study analyses the most recent trends in labour jurisprudence concerning poor performance to highlight that, contrary to what might initially appear, there is no contradiction in the latest rulings of the Supreme Court.
Marco Marazza
doaj   +1 more source

Treatment of patients with metastatic colorectal cancer and poor performance status: current evidence and challenges

open access: yesClinics, 2018
Patients with unresectable metastatic colorectal cancer live for a median of three years when treated with standard therapies. While the evidence guiding cancer-directed treatment of this disease comes from phase III trials that have mostly enrolled ...
Lucila Soares da Silva Rocha   +1 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

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