Results 91 to 100 of about 735,101 (274)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

ACR appropriateness criteria nonsurgical treatment for non-small-cell lung cancer: Poor performance status or palliative intent

, 2013
Radiation therapy plays a potential curative role in the treatment of patients with non-small-cell lung cancer with locoregional disease who are not surgical candidates and a palliative role for patients with metastatic disease.
Decker, Roy H., Ginsburg, Mark E., Willers, Henning, Chang, Joe Yujiao, Kong, Feng Ming, Rosenzweig, Kenneth E., Videtic, Gregory M.M., Kestin, Larry L., Langer, Corey J., Movsas, Benjamin, Chetty, Indrin J., Lally, Brian E.   +11 more
core   +1 more source

A phase II study of S-1 monotherapy administered for 2 weeks of a 3-week cycle in advanced gastric cancer patients with poor performance status [PDF]

, 2007
Systemic chemotherapy for gastric cancer is often associated with treatment-related toxicity, which is particularly severe in patients with a poor performance status. In this paper, we describe the first study to evaluate S-1 monotherapy as an option for
정희철, S Y Rha, H-C Jeung, S J Shin, S H Noh, J B Ahn, 신상준, 라선영, H C Chung, 정현철, J K Roh, 노재경, 안중배, 노성훈   +13 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Neurocognitive Predictors of Academic Performance in a Residential Educational Institution

Вестник Кемеровского государственного университета. Серия: гуманитарные и общественные науки
Academic success is believed to depend on one’s cognitive status. This article describes the neurocognitive predictors of academic performance in teenagers from a boarding school.
Nina V. Nemolochnaya
doaj   +1 more source

Radiotherapy Outcomes in Adults with H3K27MAltered Midline Gliomas and Poor Performance Status

Comprehensive Medicine
Objective: Treatment of H3K27M-altered midline gliomas is a significant challenge. This study aims to assess the efficacy of radiotherapy for these patients. Materials and Methods: Thirteen patients with histologically confirmed H3K27M-altered midline glioma, treated with radiotherapy +/- temozolomide be- tween 2019 and 2021, were retrospectively ...
Uzel, Esengül Koçak, Kılıç, Melisa Bağcı, Figen, Metin, Bölükbaş, Meltem Kirli, Uzel, Ömer   +4 more
openaire   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Pretreatment Lymphopenia, Poor Performance Status, and Early Courses of Therapy Are Risk Factors for Severe Bacterial Infection in Patients with Multiple Myeloma during Treatment with Bortezomib-based Regimens [PDF]

, 2017
The aim of this study was to identify the risk factors associated with severe bacterial infection (SBI) in multiple myeloma (MM) patients during treatment with bortezomib-based regimens.
민유홍, 장지은, 김윤덕, 송재우, 이정연, 한상훈, 김수정, 정준원, 김진석, 조현수   +9 more
core   +1 more source

ANALYSIS OF BASIC NEEDS ACCESSIBILITY POOR HOUSEHOLD IN DISTRICT GIANYAR

E-Journal of Cultural Studies, 2019
The purpose of this study was to analyze the basic needs of poor households in Gianyar Regency in terms of capacity, socioeconomic status, socio-cultural environment and institutional poverty reduction towards the accessibility of poor households both ...
I Nyoman Tingkes
doaj   +1 more source