Results 81 to 90 of about 735,101 (274)

Quality of Life (QoL) of cancer patients and its association with nutritional and performance status: A pilot study

Heliyon, 2020
Background: Quality of Life (QoL), for long, has been a multifactorial concerning issue in oncology. The aim of this study was to determine QoL of cancer patients and its association with nutrition, and performance status.
Mohammad Morshad Alam, Tania Rahman, Zinia Afroz, Promit Ananyo Chakraborty, Abrar Wahab, Sanjana Zaman, Mohammad Delwer Hossain Hawlader   +6 more
doaj   +1 more source

Kinetics of COVID-19 mRNA primary and booster vaccine-associated neutralizing activity against SARS-CoV-2 variants of concern in long-term care facility residents: a prospective longitudinal study in Japan

Immunity & Ageing, 2023
Background Coronavirus disease 2019 (COVID-19) remains a threat to vulnerable populations such as long-term care facility (LTCF) residents, who are often older, severely frail, and have multiple comorbidities. Although associations have been investigated
Tomoyuki Kakugawa, Keiko Doi, Yuichi Ohteru, Hiroyuki Kakugawa, Keiji Oishi, Masahiro Kakugawa, Tsunahiko Hirano, Yusuke Mimura, Kazuto Matsunaga   +8 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Rapid Efficacy of Gemtuzumab Ozogamicin in Refractory AML Patients with Pulmonary and Kidney Failure

Biology, 2020
Objectives: To the best of our knowledge, data from Gemtuzumab ozogamicin in Acute Myeloid Leukemia (AML) patients with failure of organ functions and poor performance status are extremely lacking.
Daniil Zaytsev, Larisa Girshova, Vladimir Ivanov, Irina Budaeva, Dmitri Motorin, Renat Badaev, Julia Mirolubova, Evgeni Grobovenko, Tamara Chitanava, Ekaterina Zaykova, Julia Alexeeva, Andrey Zaritskey   +11 more
doaj   +1 more source

Carboplatin and 5-fluorouracil in poor performance status patients with advanced urothelial cancer

Annals of Oncology, 1993
In view of the difficulties in administering aggressive treatment to elderly patients, frequently with concomitant medical problems, a treatment program with the combination of carboplatin and 5-FU for advanced urothelial tumors was designed. The aim was to maintain an efficacious therapeutic schedule while minimizing toxicity.Twenty-three patients ...
M G, Arena, C N, Sternberg, M, Zeuli, P, De Carli, A, Cancrini, V, Pansadoro, F, Calabresi   +6 more
openaire   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Dramatic responses to gefitinib when used as front line therapy in two cases of metastatic lung adenocarcinoma with poor performance status

, 2010
A 54-year-old man, a non-smoker, suffering from metastatic lung adenocarcinoma presented with extensive bilateral pulmonary infiltrates. He was dyspneic at rest. Performance status (PS) was 4.
Garg, Priyam, Kumar, Rakesh, Raina, Vinod, Gupta, Ajay   +3 more
core   +2 more sources

Successful management of malignant carinal involvement by “side‐by‐side” method of self‐expandable metallic stents followed by chemotherapy

Clinical Case Reports, 2018
Key Clinical Message Bilateral self‐expandable metallic stents may be useful in the management of malignant carinal involvement and may improve the performance status of patients.
Takayuki Takeda, Hideki Itano, Mayumi Takeuchi, Masahiko Saitoh, Sorou Takeda   +4 more
doaj   +1 more source

To Treat or Not to Treat Metastatic Cancer Patients with Poor Performance Status: a Prospective Experience

Pathology & Oncology Research, 2016
Administration of cytotoxic chemotherapy for patients with metastatic cancer and poor performance status is a daily clinical challenge. Guidelines only help to select a therapeutic regimen but do not offer a clear response whether or not the patients should be treated.
Tamás, Kullmann, Hélène, Gauthier, Camille, Serrate, Damien, Pouessel, Christine, le Maignan, Jean-Louis, Misset, Stéphane, Culine   +6 more
openaire   +2 more sources