Results 61 to 70 of about 735,101 (274)

A pilot study of novel duodenal covered self-expandable metal stent fixation

Scientific Reports, 2021
Migration of duodenal covered self-expandable metal stents (C-SEMSs) is the main cause of stent dysfunction in patients with malignant gastric outlet obstruction (mGOO).
Yasuki Hori, Kazuki Hayashi, Itaru Naitoh, Katsuyuki Miyabe, Makoto Natsume, Michihiro Yoshida, Hiromi Kataoka   +6 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Efficacy of Metronomic Vinorelbine in Elderly Patients with Advanced Non-Small-Cell Lung Cancer and Poor Performance Status [PDF]

, 2017
Background: Metronomic chemotherapy—administration of low-dose chemotherapy—allows for a prolonged treatment duration and minimizes toxicity for unfit patients diagnosed with advanced non-small-cell lung cancer (NSCLC).
B. Kızılkaya, Durak, S., Bilir, C., Kizilkaya, B., H. Engin, Nayir, E., B. Kizilkaya, Hacibekiroglu, I., Durak, Serdar, E. Nayır, I. Hacıbekiroglu, Hacıbekiroğlu, İlhan, Nayir, Erdinç, S. Durak, Bilir, Cemil, Engin, H., E. Nayir, Hacıbekiroğlu, I., Engin, H. Billur, Kızılkaya, Bayram, Cemil Bilir   +20 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Upper urinary tract stone disease in patients with poor performance status: active stone removal or conservative management?

BMC Urology, 2017
Background It remains controversial as to whether active stone removal should be performed in patients with poor performance status because of their short life expectancy and perioperative risks.
Shimpei Yamashita, Yasuo Kohjimoto, Yasuo Hirabayashi, Takashi Iguchi, Akinori Iba, Masatoshi Higuchi, Hiroyuki Koike, Takahito Wakamiya, Satoshi Nishizawa, Isao Hara   +9 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Durvalumab in Patients With Treatment-Naive Stage IV NSCLC With an ECOG Performance Status of 2 to 3 and High PD-L1 Tumor Expression (IFCT-1802 SAVIMMUNE): A Multicenter Phase 2 Trial

JTO Clinical and Research Reports
Introduction: Eastern Cooperative Oncology Group performance status 2 to 3 is associated with poor survival and chemotherapy-related adverse events (AEs).
Valérie Gounant, MD, Laurent Greillier, MD, PhD, Céline Mascaux, MD, PhD, François Pinquie, MD, Delphine Carmier, MD, Lionel Moreau, MD, Benoît Roch, MD, Didier Debieuvre, MD, Xavier Dhalluin, MD, Etienne Giroux-Leprieur, MD, PhD, Elodie Berton, MD, Audrey Rabeau, MD, Judith Raimbourg, MD, Adrien Dixmier, MD, Charles Naltet, MD, Antoine Khalil, MD, PhD, Lynn Ezzeddine, MD, Mostafa El Hajjam, MD, PhD, Alexandra Langlais, MSc, Franck Morin, MSc, Virginie Westeel, MD, PhD, Gérard Zalcman, MD, PhD, Michael Duruisseaux, MD, PhD   +22 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

A Case of Granulocyte-Colony-Stimulating Factor-Producing Non-Small Cell Lung Cancer under Steroid Treatment and with Poor Performance Status That Responded to Pembrolizumab. [PDF]

Case Rep Oncol
Introduction: There have been only a few cases showing the efficacy of pembrolizumab on granulocyte-colony-stimulating factor (G-CSF)-producing non-small-cell lung cancer (NSCLC) with high programmed cell death ligand 1 (PD-L1) expression.
Egusa H, Masuda T, Yamaguchi K, Sakamoto S, Horimasu Y, Kushitani K, Nakashima T, Iwamoto H, Hamada H, Hattori N.   +9 more
europepmc   +3 more sources

MTP15-01: Treatment of elderly and poor performance status patients [PDF]

Journal of Thoracic Oncology, 2007
n ...
openaire   +2 more sources