Results 151 to 160 of about 183,667 (279)

The Power and the Purse: Aspects of the Genesis and Implementation of the Metropolitan Poor Act 1867

open access: yes, 1998
PhdThis thesis examines the genesis and implementation of two provisions of the Metropolitan Poor Act 1867: rate equalisation and the appointment of central government nominees to local poor law bodies.
Ashbridge, Pauline Mary
core  

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu   +13 more
wiley   +1 more source

'Better off thrown behind a ditch': Enniskillen Workhouse during the Great Famine [PDF]

open access: yes
Famine, Poor Relief ...
Desmond McCabe, Cormac Ó Gráda
core  

Unity in diversity. Rural poor relief in the sixteenth-century Southern Low Countries

open access: yesTijdschrift voor Sociale en Economische Geschiedenis, 2015
Eline Van Onacker, Hadewijch Masure
doaj   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

open access: yesAdvanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang   +11 more
wiley   +1 more source

Hebrew Relief Society (New York, N.Y.) records undated, 1926

open access: yes
Contains a manuscript list of subscribers to the original society, signed by Asher Kursheedt, and printed copies of the Society's act of incorporation and by-laws, listing the officers, board of managers, and members for 1926Hebrew Relief Society ...
Kursheedt, Asher1808-1893   +2 more
core  

Hiccups for HIPCs? [PDF]

open access: yes
In this paper we discuss fiscal and monetary policy issues facing heavily-indebted poor countries (HIPCs) who receive debt reduction via the enhanced HIPC initiative.
Domenico Fanizza, Craig Burnside
core  

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