Results 171 to 180 of about 183,667 (279)

Kienbock's Disease in a Young Female without Classical Risk Factors: A Case Report with 1-year Functional Outcome Following Proximal Row Carpectomy. [PDF]

J Orthop Case Rep
Karthikeyan RKS, Kempulraj P, Kumar RM, Senthil V.   +3 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

The Idle, Immoral and Profligate Poor: The condition of the poor and the ‘taint of pauperism’ in Huddersfield between 1834 and 1874, with particular reference to the ‘undeserving poor’

The purpose of this research is to examine the use of popular political language and its consequence on the poor, especially the undeserving poor. The study examines how, such ‘anti-pauper language’ affected social outcomes for the poor, and how certain ...
Barrett, John Wilson
core  

Use of Cryoneurolysis Therapy for the Management of Idiopathic Trigeminal Neuralgia. [PDF]

Orthop Rev (Pavia)
Gritsenko K, Oh SM, Zakirova M, Ortiz NR, Raghavan J, Koushik S, Viswanath O, Shaparin N.   +7 more
europepmc   +1 more source

Recent Advances in Laser‐Induced Graphene‐Based Gas Sensors: From Sensing Mechanisms to Biomedical Applications

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Md Abu Sayeed Biswas, Ankan Dutta, Shuvendu Das, Abu Musa Abdullah, Wanqing Zhang, Fatema Tuz Zohra, Huanyu Cheng   +6 more
wiley   +1 more source

A pragmatic phase II trial evaluating treatment strategies using immune checkpoint inhibitors for metastatic esophageal cancer patients with severe dysphagia. [PDF]

ESMO Gastrointest Oncol
Nagata Y, Arai H, Izawa N, Inagaki C, Sugaya A, Hirata K, Tsushima T, Moriwaki T, Masuishi T, Nagatani Y, Harada K, Taguri M, Sunakawa Y.   +12 more
europepmc   +1 more source

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

A scoping review on the mental health of disaster responders for natural disasters in Japan. [PDF]

PCN Rep
Ito Y, Takahashi S, Tachikawa H, Midorikawa H, Arai T.   +4 more
europepmc   +1 more source

Atomic Defects in Layered Transition Metal Dichalcogenides for Sustainable Energy Storage and the Intelligent Trends in Data Analytics

Advanced Science, EarlyView.
This review comprehensively summarizes the atomic defects in TMDs for their applications in sustainable energy storage devices, along with the latest progress in ML methodologies for high‐throughput TEM data analysis, offering insights on how ML‐empowered microscopy facilitates bridging structure–property correlation and inspires knowledge for precise ...
Zheng Luo, Ying Yang, Zizhen Fu, Fengqi Liu, Susu Fang, Kele Xu, Shanshan Wang   +6 more
wiley   +1 more source

QUAD SHOT radiotherapy for palliation in advanced cancer: current status and future directions. [PDF]

Front Oncol
Liu X, Du ZY, Ning ZF, Liu JL, Hu YL, Huang DB.   +5 more
europepmc   +1 more source