Results 221 to 230 of about 5,294,790 (308)

Multimorbidity trends in Catalonia, 2010-21: a population-based cohort study. [PDF]

Int J Epidemiol
Permanyer I, Gumà J, Trias-Llimós S, Solé-Auró A.   +3 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Pregnancy, asthma and exacerbations: a population-based cohort. [PDF]

Eur Respir J
Lee B, Wong E, Tan T, Rupani H, Bloom CI.   +4 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Postoperative ERCP as proxy for clinically significant retained stones in a population-based cohort? [PDF]

Surg Open Sci
Liljegren E, Hedestig L, Sverdén E, Österberg J, Enochsson L, Sandblom G.   +5 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Alternative diagnoses of suspected paraneoplastic neurological syndromes: a population-based study. [PDF]

J Neurol
Vogrig A, Bax F, Gigli GL, Bernardini A, Marini A, Rana M, Passadore P, Bagatto D, Curcio F, Muñiz-Castrillo S, Honnorat J, Fabris M, Valente M.   +12 more
europepmc   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Prevalence and Spirometric Transitions of PRISm and Obstruction: A Population-Based Study. [PDF]

Respirology
Lim CJM, Mraz TL, Gross C, Irvin CG, Franssen FME, Breyer MK, Wouters EFM, Breyer-Kohansal R.   +7 more
europepmc   +1 more source