Results 61 to 70 of about 5,294,790 (308)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Physical exertion at work and addictive behaviors: tobacco, cannabis, alcohol, sugar and fat consumption: longitudinal analyses in the CONSTANCES cohort

Scientific Reports, 2022
We examined the prospective association of physical exertion at work with subsequent tobacco, cannabis, alcohol use, and sugar and fat consumption. Volunteers of the French population-based CONSTANCES cohort currently employed were included from 2012 to ...
Nadine Hamieh, Alexis Descatha, Marie Zins, Marcel Goldberg, Sébastien Czernichow, Nicolas Hoertel, Marie Plessz, Yves Roquelaure, Frédéric Limosin, Cédric Lemogne, Joane Matta, Guillaume Airagnes   +11 more
doaj   +1 more source

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

Protocol for implementation of an evidence based parentally administered intervention for preterm infants

BMC Pediatrics, 2021
Background Multi-sensory behavioral interventions for preterm infants have the potential to accelerate feeding, growth, and optimize developmental trajectories and increase parents’ interactive engagement with their infants.
Rosemary White-Traut, Debra Brandon, Karen Kavanaugh, Karen Gralton, Wei Pan, Evan R. Myers, Bree Andrews, Michael Msall, Kathleen F. Norr   +8 more
doaj   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

The association between cannabis use and adherence to COVID-19 public health guidelines: prospective analyses from the French CONSTANCES cohort and SAPRIS survey

Harm Reduction Journal
Objective To examine the association between the frequency of cannabis use and adherence to COVID-19 public health guidelines among adults in France between April and October 2020. Methods Data from the CONSTANCES cohort on 39,450 adults participating in
Rita El Haddad, Emmanuel Wiernik, Sofiane Kab, Marie Zins, Guillaume Airagnes   +4 more
doaj   +1 more source

Associations between reproductive history, hormone use, APOE ε4 genotype and cognition in middle- to older-aged women from the UK Biobank

Frontiers in Aging Neuroscience, 2023
IntroductionRelative to men, women are at a higher risk of developing age-related neurocognitive disorders including Alzheimer’s disease. While women’s health has historically been understudied, emerging evidence suggests that reproductive life events ...
Linn R. S. Lindseth, Ann-Marie G. de Lange, Ann-Marie G. de Lange, Ann-Marie G. de Lange, Dennis van der Meer, Dennis van der Meer, Ingrid Agartz, Ingrid Agartz, Ingrid Agartz, Lars T. Westlye, Lars T. Westlye, Christian K. Tamnes, Christian K. Tamnes, Christian K. Tamnes, Claudia Barth, Claudia Barth   +15 more
doaj   +1 more source

Mapping population-based structural connectomes [PDF]

NeuroImage, 2018
Advances in understanding the structural connectomes of human brain require improved approaches for the construction, comparison and integration of high-dimensional whole-brain tractography data from a large number of individuals. This article develops a population-based structural connectome (PSC) mapping framework to address these challenges.
Zhengwu, Zhang, Maxime, Descoteaux, Jingwen, Zhang, Gabriel, Girard, Maxime, Chamberland, David, Dunson, Anuj, Srivastava, Hongtu, Zhu   +7 more
openaire   +2 more sources

Romantic and sexual behavior in young adolescents : repeated surveys in a population-based cohort [PDF]

, 2010
Adverse outcomes of teenage sexual activity are common in the United Kingdom. We used a computer-assisted interview to ask young adolescents aged 11-12 years (N = 6856) and 12 -13 years (N = 6801) who were part of the Avon Longitudinal Study of Parents ...
Andrea E. Waylen, Andrew Ness, Cotton, S., Dieter Wolke, Health Behaviour in School-Aged Children Study., Nicola Low, Phil McGovern   +6 more
core   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source