Results 111 to 120 of about 10,195,814 (311)

The impact of population-based faecal occult blood test screening on colorectal cancer mortality:a matched cohort study [PDF]

, 2012
BACKGROUND: Randomised trials show reduced colorectal cancer (CRC) mortality with faecal occult blood testing (FOBT). This outcome is now examined in a routine, population-based, screening programme. METHODS: Three biennial rounds of the UK CRC screening
B Towler, C G Fraser, D H Brewster, F A Carey, G Libby, J Birrell, J Cuzick, J Faivre, J Kewenter, JD Hardcastle, JH Scholefield, JS Mandel, L Tabar, O Kronborg, OO Aalen, P L McClements, R J Black, R J C Steele, RJ Steele, RJ Steele, SM Moss, TJW Lee   +21 more
core   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Why Brazilian women suffer more from depression and suicidal ideation: a mediation analysis of the role of violence

Brazilian Journal of Psychiatry
Objective: We aimed to investigate the mediating effect of violence by a family member or acquaintance on biological sex, depression and suicidal ideation.
Marina X. Carpena, Francine dos S. Costa, Thais Martins-Silva, Mariana O. Xavier, Christian Loret de Mola   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Enfermedad Periodontal en la población joven y adulta uruguaya del Interior del país: Relevamiento Nacional 2010-2011

Odontoestomatología
Durante los años 2010-2011, la Facultad de Odontología, Udelar realizó el “Primer Relevamiento Nacional de salud bucal en población joven y adulta uruguaya”.
Susana Lorenzo, Virginia Piccardo, Fernanda Alvarez, Fernando Massa, Ramon Alvarez   +4 more
doaj  

Exploring the relationship between sleep characteristics and cardiovascular biomarkers among adults aged 46–85 years measured in the Doetinchem cohort study

Scientific Reports
We examined the associations between sleep characteristics and cardiovascular biomarkers among middle-aged and older adults from the general population and explored interactions by age and sex.
Laura W. Samson, Hanneke Wijnhoven, W. M. Monique Verschuren, H. Susan J. Picavet   +3 more
doaj   +1 more source

Comparison of hypothesis- and data-driven asthma phenotypes in NHANES 2007–2012: the importance of comprehensive data availability

Clinical and Translational Allergy, 2019
Background Half of the adults with current asthma among the US National Health and Nutrition Examination Survey (NHANES) participants could be classified in more than one hypothesis-driven phenotype.
Rita Amaral, Ana M. Pereira, Tiago Jacinto, Andrei Malinovschi, Christer Janson, Kjell Alving, João A. Fonseca   +6 more
doaj   +1 more source

Linking stage-resolved population models with field observations: an integrated approach on population dynamics of Pseudocalanus elongatus in the German Bight. [PDF]

, 2012
The population dynamics of Pseudocalanus elongatus have been investigated within the framework of the GLOBEC-Germany project to gain a better understanding of its life cycle and population dynamics and to estimate secondary production in the North Sea.
Hirche, Hans-Jürgen, Moll, Andreas, Peters, Janna, Renz, Jasmin, Stegert, Christoph   +4 more
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source