Results 251 to 260 of about 10,195,814 (311)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Healthcare Costs and Trends of Multimorbidity in COPD Patients: A Population-Based Study in Singapore. [PDF]

Int J Chron Obstruct Pulmon Dis
Juang YR, Lim LHM, Chotirmall SH, Abisheganaden J, Koh MS, Tsai MJ, Liew MF, Yii ACA, Tiew PY, Price D, Tan KB, Chen W.   +11 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Development and validation of a nomogram for overall survival in pancreatic solid pseudopapillary neoplasm: a population-based study. [PDF]

Sci Rep
Zhong P, Tao Q, Hu F.
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Autism and immigration background, insights from a population-based study. [PDF]

Paediatr Child Health
Ricci MF, Detillieux GR, Yousefiasl S, Zwaigenbaum L, Narvey S, Yogendran M, Urquia ML.   +6 more
europepmc   +1 more source

Sex differences in obstructive sleep apnea: a population-based study from northeastern Germany. [PDF]

Sleep Breath
Steinmetz K, Krüger M, Obst A, Ewert R, Penzel T, Fietze I, Kordaß B, Ittermann T, Busch CJ, Scharf C, Stracke S, Stubbe B, Daboul A.   +12 more
europepmc   +1 more source

Birth-related characteristics predict vision-related quality of life in adults: A population-based study. [PDF]

PLoS One
Philip J, Boonstra FN, Huurneman B, Jansonius NM.   +3 more
europepmc   +1 more source

Determinants of healthcare utilisation among post-COVID syndrome patients: a population-based study in Malaysia. [PDF]

Sci Rep
Sha'ari NI, Ismail A, Sk Abd Razak R, Abdul Aziz AF, Suddin LS, Azzeri A, Zamli AH, Mohd Hanaffi RH.   +7 more
europepmc   +1 more source