Dissecting genetic effects with imprinting
Frontiers in Ecology and Evolution, 2014 Models of genetic effects are mathematical representations of a genotype-to-phenotype (GP) map that, rather than accounting for a raw map assigning phenotypes to genotypes, rely on parameters with deliberate evolutionary meaning—additive and interaction ...
José M eÁlvarez-Castro +1 more
doaj +3 more sources
Disentangling the effects of geographic and ecological isolation on genetic differentiation [PDF]
, 2013 Populations can be genetically isolated both by geographic distance and by differences in their ecology or environment that decrease the rate of successful migration.
Bradburd, Gideon +2 more
core +1 more source
A synthesis of logic and biology in the design of dependable systems [PDF]
, 2015 The technologies of model-based design and dependability analysis in the design of dependable systems, including software intensive systems, have advanced in recent years.
Papadopoulos, Yiannis
core +1 more source
Adjustment of model parameters to estimate distribution transformers remaining lifespan [PDF]
, 2018 Currently, the electrical system in Argentina is working at its maximum capacity, decreasing the margin between the installed power and demanded consumption, and drastically reducing the service life of transformer substations due to overload (since the ...
Gotay Sardiñas, Jorge +3 more
core +1 more source
Application of pharmacogenomics and bioinformatics to exemplify the utility of human ex vivo organoculture models in the field of precision medicine [PDF]
, 2019 Here we describe a collaboration between industry, the National Health Service (NHS) and academia that sought to demonstrate how early understanding of both pharmacology and genomics can improve strategies for the development of precision medicines ...
A Cilli +42 more
core +2 more sources
Epigenetic Biomarkers for Environmental Exposures and Personalized Breast Cancer Prevention. [PDF]
, 2020 Environmental and lifestyle factors are believed to account for >80% of breast cancers; however, it is not well understood how and when these factors affect risk and which exposed individuals will actually develop the disease.
Park, Hannah Lui
core +1 more source
Cellular Classes in the Human Brain Revealed In Vivo by Heartbeat-Related Modulation of the Extracellular Action Potential Waveform [PDF]
, 2020 Determining cell types is critical for understanding neural circuits but remains elusive in the living human brain. Current approaches discriminate units into putative cell classes using features of the extracellular action potential (EAP); in absence of
Anastassiou, Costas A. +6 more
core
Effects of habitat and land use on breeding season density of male Asian Houbara Chlamydotis macqueenii [PDF]
, 2016 Landscape-scale habitat and land-use influences on Asian Houbara Chlamydotis macqueenii (IUCN Vulnerable) remain unstudied, while estimating numbers of this cryptic, low-density, over-hunted species is challenging.
A Johnston +50 more
core +1 more source
, 2014 Genetic association analyses often involve data from multiple potentially-heterogeneous subgroups. The expected amount of heterogeneity can vary from modest (e.g., a typical meta-analysis) to large (e.g., a strong gene--environment interaction). However,
Stephens, Matthew, Wen, Xiaoquan
core +1 more source
Different genes interact with particulate matter and tobacco smoke exposure in affecting lung function decline in the general population [PDF]
, 2012 BACKGROUND: Oxidative stress related genes modify the effects of ambient air pollution or tobacco smoking on lung function decline. The impact of interactions might be substantial, but previous studies mostly focused on main effects of single genes ...
A Comandini +76 more
core +7 more sources