Results 151 to 160 of about 13,472,802 (342)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Population health management within the primary care context - scoping review. [PDF]

open access: yesEur J Gen Pract
Schaubroeck E   +4 more
europepmc   +1 more source

The Population Ecology of Organizations

open access: yesAmerican Journal of Sociology, 1977
M. Hannan, John A. Freeman
semanticscholar   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

open access: yesMolecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Population data on Finland 1900-1984

open access: yesFinnish Yearbook of Population Research, 1985
Population Research Institute
doaj  

Nutritional adaptation in the marine to freshwater establishment process - how do diet and genotype shape phenotype? [PDF]

open access: yesJ Exp Biol
Twining CW   +12 more
europepmc   +1 more source

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