Results 61 to 70 of about 11,560,181 (351)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Prediction of the relationship between body weight and body condition score in sheep [PDF]

, 2003
During the whole production cycle it is important to monitor the energy balance and to quantify body reserve changes of the ewes. This can be done, both in experimental settings and in the field, by estimating the body condition score (BCS) of the ewes ...
Boe, Filippo, Cannas, Antonello
core  

The formation of permanent soft binaries in dispersing clusters

, 2011
Wide, fragile binary stellar systems are found in the galactic field, and have recently been noted in the outskirts of expanding star clusters in numerical simulations.
Aarseth, Aarseth, Adams, Bate, Baumgardt, Bressert, Casertano, Cathie J. Clarke, Duquennoy, Fischer, Gieles, Giersz, Goodman, Gürkan, Heggie, Heggie, Hills, Hénon, Jiang, King, Kouwenhoven, Kroupa, Kroupa, Kroupa, Lada, Lynden Bell, Mallada, Moeckel, Nickolas Moeckel, Parker, Plummer, Porras, Raghavan, Retterer, Scally, Spitzer, Weinberg   +36 more
core   +1 more source

Population balance modelling for a flow induced phase inversion based granulation in a two-dimensional rotating agglomerator [PDF]

, 2010
A novel two-dimensional rotating agglomerator was developed to carry out the flow induced phase inversion (FIPI) based granulation. The process in this agglomerator shows that a continuous paste flow (mixed with liquid binder and primary particles) is ...
Akay, Akay, Akay, Akay, Bird, Ennis, G. Akay, Gaylord, German, Ghijsels, Hill, Hounslow, Hounslow, Hulbert, L. Liu, L. Tong, Lissant, Liu, Milewski, Nielsen, Paul, Ramkrishna, Randolph, Sastry, Van de Vegt, von Smoluchowski, Wildemuth   +26 more
core   +1 more source

Population adaptation in efficient balanced networks

eLife, 2017
Adaptation is a key component of efficient coding in sensory neurons. However, it remains unclear how neurons can provide a stable representation of external stimuli given their history-dependent responses. Here we show that a stable representation is maintained if efficiency is optimized by a population of neurons rather than by neurons individually ...
Gutierrez, Gabrielle J., Denève, Sophie
openaire   +3 more sources

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Annual severity increment score as a tool for stratifying patients with Niemann-Pick disease type C and for recruitment to clinical trials

Orphanet Journal of Rare Diseases, 2018
Background Niemann-Pick disease type C (NPC) is a lysosomal storage disease with a heterogeneous neurodegenerative clinical course. Multiple therapies are in clinical trials and inclusion criteria are currently mainly based on age and neurological signs,
Mario Cortina-Borja, Danielle te Vruchte, Eugen Mengel, Yasmin Amraoui, Jackie Imrie, Simon A. Jones, Christine i Dali, Paul Fineran, Thomas Kirkegaard, Heiko Runz, Robin Lachmann, Tatiana Bremova-Ertl, Michael Strupp, Frances M. Platt   +13 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Endogenous Quasicycles and Stochastic Coherence in a Closed Endemic Model

, 2010
We study the role of demographic fluctuations in typical endemics as exemplified by the stochastic SIRS model. The birth-death master equation of the model is simulated using exact numerics and analysed within the linear noise approximation.
C. W. Gardiner, E. Schrödinger, G. F. Raggett, J. D. Murray, M. S. Bartlett, N. G. van Kampen, R. Adhikari, R. M. Nisbet, Somdeb Ghose   +8 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source