Results 91 to 100 of about 2,626,290 (294)

The Reproductive Value in Distributed Optimal Control Models [PDF]

open access: yes
We show that in a large class of distributed optimal control models (DOCM), where population is described by a McKendrick type equation with an endogenous number of newborns, the reproductive value of Fisher shows up as part of the shadow price of the ...
Alexia Prskawetz   +3 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Cuticular component analysis for discrimination of Aedes aegypti (diptera: culicidae) from seven localities in South Kalimantan

open access: yesJournal of Biological Researches, 2008
Cuticular components of female Aedes aegypti from seven localities (populations) in South Kalimantan were compared. Mosquitoes from four populations of Banjarmasin, and one population each of Pelaihari, Barabai, and Kotabaru were sampled.
Abdul Gafur
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Population Dynamics and Non-Hermitian Localization

open access: yes, 1999
We review localization with non-Hermitian time evolution as applied to simple models of population biology with spatially varying growth profiles and convection.
A.R. Robinson   +23 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Life history traits of the glass knifefish Eigenmannia desantanai (Gymnotiformes: Sternopygidae) in the Southern Pantanal, Brazil [PDF]

open access: yesActa Limnologica Brasiliensia
Aim This study investigated life-history traits of Eigenmannia desantanai in the southern Pantanal floodplain. Methods Fish were collected beneath stands of aquatic macrophytes using seine nets and rectangular sieves with a 2 mm mesh size in the ...
Karina Keyla Tondato-Carvalho   +5 more
doaj   +1 more source

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