Results 81 to 90 of about 857,131 (297)

European regional population decline and policy responses: three case studies

open access: yes, 2012
Universal processes related to the demographic transition to structural low fertility on the one hand, and economic geographic processes of concentration and urbanization on the other lead to regional population decline in most European countries. Due to
Galjaard, R.   +7 more
core   +1 more source

Scientific and technical assistance concerning the survival, establishment and spread of Batrachochytrium salamandrivorans (Bsal) in the EU

open access: yesEFSA Journal, 2017
A new fungus, Batrachochytrium salamandrivorans (Bsal), was identified in wild populations of salamanders in the Netherlands and Belgium, and in kept salamander populations in Germany and the United Kingdom.
European Food Safety Authority (EFSA)   +11 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Assessing the extinction risk of tree species in the subtropical Atlantic Forest using multiple IUCN criteria

open access: yesOryx
The Atlantic Forest is one of the most threatened tropical forests in the world. Many species have declined and become isolated because of pervasive forest loss and degradation. Here we assess the current population status of Atlantic Forest tree species
Guilherme Salgado Grittz   +4 more
doaj   +1 more source

The Population Decline and Extinction of Darwin’s Frogs

open access: yesPLoS ONE, 2013
Darwin's frogs (Rhinoderma darwinii and R. rufum) are two species of mouth-brooding frogs from Chile and Argentina. Here, we present evidence on the extent of declines, current distribution and conservation status of Rhinoderma spp.; including information on abundance, habitat and threats to extant Darwin's frog populations.
Soto Azat, Claudio   +5 more
openaire   +6 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Like high cholesterol, population decline is a problem, but not in the way you might think...

open access: yes, 2023
The prospect of population decline in Europe is commonly understood to be an important policy problem. Discussions and research typically focus on the level and the trend of demographic indicators.
Wendy Sigle, Sigle, Wendy
core   +1 more source

The continued decline of the Palila ( Loxioides bailleui ) on Mauna Kea, Island of Hawaiʻi

open access: yesAvian Conservation and Ecology
Palila ( Loxioides bailleui ) are critically endangered Hawaiian honeycreepers specializing on māmane ( Sophora chrysophylla ) seeds and restricted to Mauna Kea volcano on the Island of Hawaiʻi.
Noah J. Hunt   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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