Results 141 to 150 of about 3,143,816 (338)
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
BuildingsWith the gradual increase in population density, population migration poses unprecedented challenges to urban environments and their capacity. The fresh air system effectively ensures fresh air in indoor environments. An important parameter affecting the
Daqian Tang +3 more
doaj +1 more source
Anthropogenic and climatic drivers of population densities in an African savanna ungulate community [PDF]
, 2023 Lukas Bierhoff +3 more
openalex +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
, 2010 The majority of the Canadian population, about 60% is concentrated within a thin belt of land representing 2.2% of the land between Windsor, Ontario and Quebec City. Even though Canada is the second largest country in the world in terms of land area, it only ranks 33rd in terms of population.
openaire +1 more source
Modelling population density over time: how spatial distance matters
, 2015 Ilenia Epifani, Rosella Nicolini
openalex +2 more sources
Community natural resource management: the case of woodlots in northern Ethiopia [PDF]
This paper examines the nature of community management of woodlots and investigates the determinants of collective action and its effectiveness in managing woodlots, based on a survey of 100 villages in Tigray, northern Ethiopia.
Gebremedhin, Berhanu +2 more
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source