Results 121 to 130 of about 8,466,171 (303)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Neoclassical growth models and the optimum rate of population growth (with applications to underdeveloped countries) [PDF]
, 1970 For more about the East-West Center, see http://www.eastwestcenter.org/Among economists who are also interested in demography, there is a respectable tradition of analysis revolving around the concept of a static optimum population. The work of W.
Crouch, Robert L. +1 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Components of regional population growth, 1986-2001 [PDF]
, 2004 The vitality of a region is frequently assessed by looking at its population growth pattern. This is seen as being linked to its economic and social vibrancy.
Pool, Ian +2 more
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This chapter will review in detail the behavior of the population density in Mexico from 1990 to 2020. The Time Series Graph of this factor will be decom- ´ posed into the Trend T(t), Seasonal S(t), Cyclical C(t), and Irregular I(t) components. From the graphical results, we will analyze and obtain will get a method to calculate the population density ...
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Population research in the Pacific Islands : a case study and some reflections [PDF]
, 1971 For more about the East-West Center, see http://www.eastwestcenter.org/This paper outlines the aims and methods (rather than the results) of a study of population movement undertaken in the British Solomon Islands Protectorate between October 1965 and ...
East-West Population Institute +1 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Population Bulletin, VOL. 75, NO. 1
, 2021 This is an overview of important demographic processes including fertility, mortality, and migration, and their effects on population growth, decline, and composition. The authors describe changes in the geographic distribution of the world’s population,
Mather, Mark +2 more
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