Results 71 to 80 of about 1,325,954 (330)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Genetic diversity and conservation in Bromeliaceae based on SSR markers [PDF]

Genetics and Molecular Biology
Bromeliaceae has been used as a model Neotropical group to study evolutionary and diversification processes. Moreover, since large parts of the Neotropics are under anthropogenic pressure, a high percentage of possibly threatened species occurs.
Milene Ferreira Barcellos, Laís Mara Santana Costa, Fernanda Bered   +2 more
doaj   +1 more source

Admixture Correction in the Outgroup-f3 Statistic [PDF]

, 2018
Genetic inheritance can be studied within a purely genetic scope. However, this eliminates part of the picture. The field of genetics is often thought of as a natural science with little in common with fields of social science. However, in human genetics
Tunga, Nita
core   +1 more source

The Etruscans: A Population-Genetic Study [PDF]

The American Journal of Human Genetics, 2004
The origins of the Etruscans, a non-Indo-European population of preclassical Italy, are unclear. There is broad agreement that their culture developed locally, but the Etruscans' evolutionary and migrational relationships are largely unknown. In this study, we determined mitochondrial DNA sequences in multiple clones derived from bone samples of 80 ...
C. Vernesi, D. Caramelli, I. Dupanloup, G. Bertorelle, M. Lari, E. Cappellini, J. Moggi-Cecchi, B. Chiarelli, L. Castri, CASOLI, ANTONELLA, F. Mallegni, C. Lalueza-Fox, G. Barbujani   +12 more
openaire   +6 more sources

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Model inspired by population genetics to study fragmentation of brittle plates

, 2007
We use a model whose rules were inspired by population genetics, the random capability growth model, to describe the statistical details observed in experiments of fragmentation of brittle platelike objects, and in particular the existence of (i ...
de Oliveira, Viviane M., Gomes, M. A. F.
core   +1 more source

Genes Classical And Genes Developmental: The Different Uses Of The Gene In Evolutionary Synthesis [PDF]

, 2000
Dobzhansky (1964) stated that “Nothing in biology makes sense except in the light of evolution,” and the function of the gene is no exception. The use of genes in population genetics and developmental genetics differs significantly.
Gilbert, Scott F.
core   +3 more sources

The Genetic Structure of the Swedish Population [PDF]

PLoS ONE, 2011
Patterns of genetic diversity have previously been shown to mirror geography on a global scale and within continents and individual countries. Using genome-wide SNP data on 5174 Swedes with extensive geographical coverage, we analyzed the genetic structure of the Swedish population.
Pamela Sklar, Pamela Sklar, Leif Groop, Jianfeng Xu, Alexander Grankvist, Henrik Grönberg, Colm O'Dushlaine, Colm O'Dushlaine, Lars Klareskog, Per Hall, Juni Palmgren, Juni Palmgren, Patrick F. Sullivan, Christina M. Hultman, Samuli Ripatti, Samuli Ripatti, Patrik K. E. Magnusson, Bo Ding, Shaun Purcell, Shaun Purcell, Monica Leu, Morten Mattingsdal, Paul Lichtenstein, Keith Humphreys, Ole A. Andreassen, Ole A. Andreassen, Nancy L. Pedersen, Karola Rehnström, Jianjun Liu   +28 more
openaire   +7 more sources

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

Faster model-based estimation of ancestry proportions

Peer Community Journal
Ancestry estimation from genotype data in unrelated individuals has become an essential tool in population and medical genetics to understand demographic population histories and to model or correct for population structure.
Santander, Cindy G., Refoyo Martinez, Alba, Meisner, Jonas   +2 more
doaj   +1 more source