Results 181 to 190 of about 4,860 (216)

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

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Population Genomics

2022
AbstractSequencing all or part of the genome of individuals from different populations allows for many analyses of genetic variation that are not possible with a small number of unlinked markers. Genomic datasets may include sequences of anonymous regions scattered throughout the genome, sequences of targeted regions such as exomes, whole genome ...
Fred W. Allendorf, W. Chris Funk, Sally N. Aitken, Margaret Byrne, Gordon Luikart   +4 more
openaire   +1 more source

Population genomics of Klebsiella pneumoniae

Nature Reviews Microbiology, 2020
Klebsiella pneumoniae is a common cause of antimicrobial-resistant opportunistic infections in hospitalized patients. The species is naturally resistant to penicillins, and members of the population often carry acquired resistance to multiple antimicrobials. However, knowledge of K.
Margaret Lam, Kelly Wyres, Kathryn Holt   +2 more
exaly   +3 more sources

Population genomics and speciation

Genetica, 2008
The process of speciation begins with genomically-localised barriers to gene exchange associated with loci for local adaptation, intrinsic incompatibility or assortative mating. The barrier then spreads until reproductive isolation influences the whole genome.
openaire   +2 more sources

Population Genomics and Phylogeography

2019
Population genetics is the study of genetic variation within populations and how allele frequencies change over space and time. This field largely focuses on the five fundamental evolutionary processes that influence genetic variation: mutation, genetic drift, gene flow, natural selection, and recombination.
Ottenburghs, J., Lavretsky, P., Peters, J., Kawakami, T., Kraus, R.   +4 more
openaire   +2 more sources

Population Genomics of Drug Response

American Journal of PharmacoGenomics, 2004
Genetic diversity contributes to both disease susceptibility and variability in response to drugs. However, it has proven difficult to isolate genes that underlie common complex disease, and genetic variations that influence clinical responses to drugs remain largely uncovered.
Eva, Halapi, Kari, Stefansson, Hakon, Hakonarson   +2 more
openaire   +2 more sources

Introduction to Population Genomics Methods

2020
High-throughput sequencing technologies have provided an unprecedented opportunity to study the different evolutionary forces that have shaped present-day patterns of genetic diversity, with important implications for many directions in plant biology research.
Leroy, Thibault, Rougemont, Quentin
openaire   +3 more sources

Populating Genomes in a Dynamic Grid

2004
We study the behavior of a spatially distributed GA (Collins and Jefferson 1991) that has several unique features. First, individuals are allowed to move within a two dimensional grid over time. Such movement results in a continual change in the local environment in which each individual interacts. Second, selection is directly based on an individual’s
Yu, Han, Jiang, Ning, Wu, Annie S.
openaire   +2 more sources

Population Genomics of Adaptive Radiation

Molecular Ecology
Adaptive radiations are rich laboratories for exploring, testing, and understanding key theories in evolution and ecology because they offer spectacular displays of speciation and ecological adaptation. Particular challenges to the study of adaptive radiation include high levels of species richness, rapid speciation, and gene flow between species. Over
Lucia L. Combrink, Jimena Golcher‐Benavides, Alexander L. Lewanski, Jessica A. Rick, William C. Rosenthal, Catherine E. Wagner   +5 more
openaire   +2 more sources

Genomic Boundaries between Human Populations

Human Heredity, 2006
Different authors disagree on whether human genome variation should be described as continuous or discontinuous; in the latter case, by attributing an individual’s genotype to one genetic cluster, one would also obtain information on the individual’s genome in general. An analysis of 377 microsatellites of the CEPH human diversity panel was interpreted
BARBUJANI, Guido, BELLE, Elise Manuele Sara   +1 more
openaire   +2 more sources