Results 51 to 60 of about 661,661 (299)

Population genomics reveals evolution and variation of Saccharomyces cerevisiae in the human and insects gut [PDF]

, 2019
The quest to discover the variety of ecological niches inhabited by Saccharomyces cerevisiae has led to research in areas as diverse as wineries, oak trees, and insect guts.
Berná, Luisa, Cavalieri, Duccio, Dapporto, Leonardo, De Filippo, Carlotta, Di Paola, Monica, Lenucci, Marcello S., Lionetti, Paolo, Ramazzotti, Matteo, Rivero, Damariz, Rizzetto, Lisa, Stefanini, Irene, Tocci, Noemi, Weil, Tobias   +12 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Understanding Disease Susceptibility through Population Genomics [PDF]

Genomics & Informatics, 2012
Genetic epidemiology studies have established that the natural variation of gene expression profiles is heritable and has genetic bases. A number of proximal and remote DNA variations, known as expression quantitative trait loci (eQTLs), that are ...
Seonggyun Han, Junnam Lee, Sangsoo Kim
doaj   +1 more source

Effect of competing mortality risks on predictive performance of the QFracture-2012 risk prediction tool for major osteoporotic fracture and hip fracture: external validation cohort study in a UK primary care population

BMJ Medicine, 2022
Objective To externally evaluate the QFracture-2012 risk prediction tool for predicting the risk of major osteoporotic fracture and hip fracture.Design External validation cohort study.Setting UK primary care population. Linked general practice (Clinical
Bruce Guthrie, Peter Donnan, Megan McMinn, Daniel R Morales, Shona J Livingstone, Chima Eke   +5 more
doaj   +1 more source

Genomics knowledge and attitudes among European public health professionals. Results of a cross-sectional survey [PDF]

, 2020
Background The international public health (PH) community is debating the opportunity to incorporate genomic technologies into PH practice. A survey was conducted to assess attitudes of the European Public Health Association (EUPHA) members towards their
Baccolini, V., Barnhoorn, F., D'Andrea, E., de Vito, C., Marco, M. D., Marzuillo, C., Paget, D. Z., Pitini, E., Rosso, A., Unim, B., Villari, P.   +10 more
core   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Perceived barriers to and facilitators of physical activity, using the COM-B model for behavioural change, in people with chronic pain: a qualitative evaluation of patient and stakeholder perspectives

BMC Public Health
Background Physical inactivity is a substantial public health concern and challenging problem to address. Physical activity (PA) is shown to be of therapeutic benefit to those living with chronic pain (CP), but intervention studies have often been ...
Cassie Higgins, PM Dall, C. Leese, P. Adair, PA Cameron, SK Inglis, A. Christogianni, BH Smith, L. Colvin   +8 more
doaj   +1 more source

Effect of competing mortality risks on predictive performance of the QRISK3 cardiovascular risk prediction tool in older people and those with comorbidity: external validation population cohort study

The Lancet. Healthy Longevity, 2021
Summary: Background: Primary prevention of cardiovascular disease (CVD) is guided by risk-prediction tools, but these rarely account for the risk of dying from other conditions (ie, competing mortality risk).
Shona Livingstone, MSc, Daniel R Morales, PhD, Peter T Donnan, ProfPhD, Katherine Payne, ProfPhD, Alexander J Thompson, PhD, Ji-Hee Youn, PhD, Bruce Guthrie, ProfPhD   +6 more
doaj   +1 more source

A haplotype-resolved draft genome of the European sardine (Sardina pilchardus) [PDF]

, 2019
The European sardine (Sardina pilchardus Walbaum, 1792) is culturally and economically important throughout its distribution. Monitoring studies of sardine populations report an alarming decrease in stocks due to overfishing and environmental change ...
Canario, A.V.M., Cox, Cymon, De Moro, Gianluca, Garcia, Carlos, Louro, Bruno, Sabatino, Stephen J., Santos, António M., Veríssimo, Ana   +7 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source