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Statistical Population Genomics

, 2020
This open access volume presents state-of-the-art inference methods in population genomics, focusing on data analysis based on rigorous statistical techniques. After introducing general concepts related to the biology of genomes and their evolution, the book covers state-of-the-art methods for the analysis of genomes in populations, including ...
openaire   +4 more sources

Population Genomics of Secondary Contact [PDF]

Genes, 2010
One common form of reticulate evolution arises as a consequence of secondary contact between previously allopatric populations. Using extensive coalescent simulations, we describe the conditions for, and extent of, the introgression of genetic material into the genome of a colonizing population from an endemic population.
Geneva, Garrigan
openaire   +2 more sources

Inference of Bacterial Pathogen Instantaneous Population Growth Dynamics

Molecular Plant-Microbe Interactions, 2020
Although bacterial host colonization is a dynamic process that requires population growth, studies often focus on comparing bacterial populations at a given time point. However, this may not reflect the dynamics of the colonization process.
Anne Sicard, Andreina I. Castillo, Michael Voeltz, Hongyu Chen, Adam R. Zeilinger, Leonardo De La Fuente, Rodrigo P. P. Almeida   +6 more
doaj   +1 more source

Remapping of the belted phenotype in cattle on BTA3 identifies a multiplication event as the candidate causal mutation

Genetics Selection Evolution, 2018
Background It has been known for almost a century that the belted phenotype in cattle follows a pattern of dominant inheritance. In 2009, the approximate position of the belt locus in Brown Swiss cattle was mapped to a 922-kb interval on bovine ...
Sophie Rothammer, Elisabeth Kunz, Stefan Krebs, Fanny Bitzer, Andreas Hauser, Natalia Zinovieva, Nikolai Klymiuk, Ivica Medugorac   +7 more
doaj   +1 more source

Association of Gut Microbiota-Derived Short-Chain Fatty Acids With Persistent Elevated Serum Transaminase Levels in Normal Weight and Obesity: A Pilot Study

Journal of Nutrition and Metabolism
Although obesity is the most common risk factor for hepatic steatosis, this disease may occur in normal-weight individuals. While gut microbial metabolites such as short-chain fatty acids (SCFAs) have been associated with obesity and metabolic disease ...
David Alberto Díaz de Sandy-Galán, Hugo Villamil-Ramírez, Maricela Rodríguez-Cruz, Blanca López-Contreras, Paola León-Mimila, Marisol Olivares-Arévalo, Jorge Maldonado-Hernández, Israel Domínguez-Calderon, Jorge Salmerón, Daniel Cerqueda-García, Teresa Villarreal-Molina, Rafael Velázquez-Cruz, Samuel Canizales-Quinteros   +12 more
doaj   +1 more source

Central Nervous System Neuroblastoma, FOXR2‐Activated: A Pooled Analysis of Published Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) neuroblastoma, FOXR2‐activated, is a recently recognized entity in the WHO CNS5 classification, defined by activation of the FOXR2 transcription factor and unique histopathological features. This review synthesizes available literature and pooled clinical data, providing insight into demographics ...
Sudarshawn Damodharan, Mohamed S. Abdelbaki   +1 more
wiley   +1 more source

Population Genomics of Russian populations

Nauchno-prakticheskii zhurnal «Medicinskaia genetika», 2020
Популяционная геномика человека является мощным современным подходом в популяционной генетике, базирующемся на технологиях геномного секвенирования, биоинформатики и анализа больших данных. Геномный анализ генетической вариабельности в популяциях является фундаментальной основой генетики болезней и разработки путей их диагностики, терапии и ...
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Enabling Population and Quantitative Genomics

Genetical Research, 2002
Dissection of quantitative traits to the nucleotide level requires phenotypic and genotypic analysis of traits on a genome scale. Here we discuss the set of community-wide genetic and molecular resources, including panels of specific types of inbred lines and high density resequencing and SNP detection, that will facilitate such studies.
Gibson, Greg, Mackay, Trudy F. C.
openaire   +5 more sources

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source

Clinical risk factors for unscheduled health care attendance for chronic pain management, and associated treatment costs

PAIN Reports
. Introduction:. Effective community-based chronic noncancer pain (CNCP) management could improve treatment outcomes and reduce the burden placed on unscheduled care (USC) services. Objectives:.
Cassie Higgins, Blair H. Smith, Lesley Colvin   +2 more
doaj   +1 more source