Results 21 to 30 of about 661,661 (299)

Population genomics of parallel adaptation [PDF]

Molecular Ecology, 2020
Parallel evolution is one of the striking patterns in nature. The presence of repeated evolution of the same phenotypes, suites of traits, and adaptations suggests a strong role for natural selection in shaping biological diversity. The reasoning is straightforward: each instance of repeated evolution makes it less likely that these features evolved ...
Meng Yuan, John R. Stinchcombe
openaire   +2 more sources

Population genomics of domestic and wild yeasts [PDF]

, 2008
The natural genetics of an organism is determined by the distribution of sequences of its genome. Here we present one- to four-fold, with some deeper, coverage of the genome sequences of over seventy isolates of the domesticated baker's yeast ...
A Demogines, A Goffeau, Alan M. Moses, Alex N. Nguyen, Alexander van Oudenaarden, Anders Blomberg, Austin Burt, Casey M. Bergman, David B. H. Barton, David M. Carter, DM Carter, DM Ruderfer, Douda Bensasson, E Aa, E Mancera, Edward J. Louis, Elizabeth Bailes, F Tajima, F Wiens, Frances Smith, G Liti, G Liti, GI Naumov, Gianni Liti, HA Kuehne, HW Mewes, Ian Goodhead, Ian N. Roberts, IJ Tsai, IS Pretorius, Isheng J. Tsai, J Diamond, J Warringer, JC Fay, JH McDonald, JK Pritchard, JL Legras, Jonas Warringer, JP Sampaio, Leopold Parts, M Bulmer, M Kellis, Matthew Jones, Michael A. Quail, Michael J. T. O’Kelly, N Siva, PD Sniegowski, Richard Durbin, RM Clark, Robert P. Davey, Sarah Sims, Stephen A. James, V Koufopanou, Vassiliki Koufopanou, W Wei   +54 more
core   +2 more sources

A publication-wide association study (PWAS), historical language models to prioritise novel therapeutic drug targets

Scientific Reports, 2023
Most biomedical knowledge is published as text, making it challenging to analyse using traditional statistical methods. In contrast, machine-interpretable data primarily comes from structured property databases, which represent only a fraction of the ...
David Narganes-Carlón, Daniel J. Crowther, Ewan R. Pearson   +2 more
doaj   +1 more source

Population genomics of the Asian tiger mosquito, Aedes albopictus. Insights into the recent worldwide invasion [PDF]

, 2017
Aedes albopictus, the “Asian tiger mosquito,” is an aggressive biting mosquito native to Asia that has colonized all continents except Antarctica during the last ~30–40 years. The species is of great public health
Aguirre-Obando, Alexander, Armbruster, Baird, Becker, Beebe, Benedict, Birungi, Bonizzoni, Brady, Brown, Chen, Chen, Chouin-Carneiro, Dalla Pozza, Damal, Danecek, Das, Delatte, Denlinger, Eaton, Egizi, Emerson, Excoffier, Flacio, Foll, Frichot, Galtier, Gloria-Soria, Goubert, Gratz, Hawley, Hemingway, Hurst, Ismail, Jackson, Jombart, Kambhampati, Kambhampati, Kamgang, Kamgang, Kasai, Lamballerie, Lambrechts, Langmead, Lewis, Li, Lischer, Liu, Lounibos, Lounibos, Lourenco de Oliveira, Luu, Manni, Manni, Marcombe, Maynard, Medley, Medlock, Minard, Morens, Mori, Mousson, Nazareno, O'Donnell, Patterson, Paupy, Pech-May, Peterson, Porretta, Porretta, Powell, Puckett, Reiter, Smartt, Sprenger, Stamatakis, Tatem, Trucchi, Urbanelli, Urbanski, Willing, Wong, Wray, Wu, Xu, Zhong   +86 more
core   +2 more sources

Coalescence 2.0: a multiple branching of recent theoretical developments and their applications [PDF]

, 2014
Population genetics theory has laid the foundations for genomics analyses including the recent burst in genome scans for selection and statistical inference of past demographic events in many prokaryote, animal and plant species.
Lemaire, Christophe, Tellier, Aurelien
core   +5 more sources

Population Genomics: Ageing by Association [PDF]

Current Biology, 2002
Mutations in the gene Klotho lead to premature ageing in mice. Recent work on human genetic variation has identified an association between a particular allele of Klotho and human lifespan. A harbinger of things to come, this work illustrates the power and growth potential for association studies of human ageing.
Pletcher, Scott D, Stumpf, Michael P.H
openaire   +2 more sources

Is ‘likely pathogenic’ really 90% likely? Reclassification data in ClinVar

Genome Medicine, 2019
In 2015, professional guidelines defined the term ‘likely pathogenic’ to mean with a 90% chance of pathogenicity. To determine whether current practice reflects this definition, ClinVar classifications were tracked from 2016 to 2019.
Steven M. Harrison, Heidi L. Rehm
doaj   +1 more source

A tug-of-war between driver and passenger mutations in cancer and other adaptive processes [PDF]

, 2014
Cancer progression is an example of a rapid adaptive process where evolving new traits is essential for survival and requires a high mutation rate. Precancerous cells acquire a few key mutations that drive rapid population growth and carcinogenesis ...
Korolev, Kirill S., McFarland, Christopher, Mirny, Leonid   +2 more
core   +2 more sources

Statistical Population Genomics

, 2020
This open access volume presents state-of-the-art inference methods in population genomics, focusing on data analysis based on rigorous statistical techniques. After introducing general concepts related to the biology of genomes and their evolution, the book covers state-of-the-art methods for the analysis of genomes in populations, including ...
openaire   +3 more sources

Population Genomics of Human Adaptation [PDF]

Annual Review of Ecology, Evolution, and Systematics, 2013
Recent advances in genotyping technologies have facilitated genome-wide scans for natural selection. Detecting targets of natural selection sheds light on human evolution and it can help identify genetic variants that influence normal human phenotypic variation as well as disease susceptibility.
Joseph, Lachance, Sarah A, Tishkoff
openaire   +2 more sources