Results 21 to 30 of about 4,860 (216)

Assessing the impact of a national clinical guideline for the management of chronic pain on opioid prescribing rates: a controlled interrupted time series analysis

Implementation Science, 2022
Background Opioids can be effective analgesics, but long-term use may be associated with harms. In 2013, the first national, comprehensive, evidence-based pain management guideline was published, from the Scottish Intercollegiate Guideline Network (SIGN ...
Harry L. Hébert, Daniel R. Morales, Nicola Torrance, Blair H. Smith, Lesley A. Colvin   +4 more
doaj   +1 more source

Excessive polypharmacy and potentially inappropriate prescribing in 147 care homes: a cross-sectional study

BJGP Open, 2021
Background: Care home residents often have multiple cognitive and physical impairments, and are at high risk of adverse drug events (ADEs). Aim: To describe excessive polypharmacy and potentially inappropriate prescribing predisposing care home residents
Clare MacRae, David AG Henderson, Stewart W Mercer, Jenni Burton, Nicosha De Souza, Paula Grill, Charis Marwick, Bruce Guthrie   +7 more
doaj   +1 more source

Population genomics of the Viking world [PDF]

Nature, 2020
The maritime expansion of Scandinavian populations during the Viking Age (about AD 750-1050) was a far-flung transformation in world history1,2. Here we sequenced the genomes of 442 humans from archaeological sites across Europe and Greenland (to a median depth of about 1×) to understand the global influence of this expansion. We find the Viking period
Margaryan, Ashot, Lawson, Daniel J, Sikora, Martin, Racimo, Fernando, Rasmussen, Simon, Moltke, Ida, Cassidy, Lara M, Jørsboe, Emil, Ingason, Andrés, Pedersen, Mikkel W, Korneliussen, Thorfinn, Wilhelmson, Helene, Buś, Magdalena M, de Barros Damgaard, Peter, Martiniano, Rui, Renaud, Gabriel, Bhérer, Claude, Moreno-Mayar, J Víctor, Fotakis, Anna K, Allen, Marie, Allmäe, Raili, Molak, Martyna, Cappellini, Enrico, Scorrano, Gabriele, McColl, Hugh, Buzhilova, Alexandra, Fox, Allison, Albrechtsen, Anders, Schütz, Berit, Skar, Birgitte, Arcini, Caroline, Falys, Ceri, Jonson, Charlotte Hedenstierna, Błaszczyk, Dariusz, Pezhemsky, Denis, Turner-Walker, Gordon, Gestsdóttir, Hildur, Lundstrøm, Inge, Gustin, Ingrid, Mainland, Ingrid, Potekhina, Inna, Muntoni, Italo M, Cheng, Jade, Stenderup, Jesper, Ma, Jilong, Gibson, Julie, Peets, Jüri, Gustafsson, Jörgen, Iversen, Katrine H, Simpson, Linzi, Strand, Lisa, Loe, Louise, Sikora, Maeve, Florek, Marek, Vretemark, Maria, Redknap, Mark, Bajka, Monika, Pushkina, Tamara, Søvsø, Morten, Grigoreva, Natalia, Christensen, Tom, Kastholm, Ole, Uldum, Otto, Favia, Pasquale, Holck, Per, Sten, Sabine, Arge, Símun V, Ellingvåg, Sturla, Moiseyev, Vayacheslav, Bogdanowicz, Wiesław, Magnusson, Yvonne, Orlando, Ludovic, Pentz, Peter, Jessen, Mads Dengsø, Pedersen, Anne, Collard, Mark, Bradley, Daniel G, Jørkov, Marie Louise, Arneborg, Jette, Lynnerup, Niels, Price, Neil, Gilbert, M Thomas P, Allentoft, Morten E, Bill, Jan, Sindbæk, Søren M, Hedeager, Lotte, Kristiansen, Kristian, Nielsen, Rasmus, Werge, Thomas, Willerslev, Eske   +89 more
openaire   +11 more sources

Population Genomics: Ageing by Association [PDF]

Current Biology, 2002
Mutations in the gene Klotho lead to premature ageing in mice. Recent work on human genetic variation has identified an association between a particular allele of Klotho and human lifespan. A harbinger of things to come, this work illustrates the power and growth potential for association studies of human ageing.
Pletcher, Scott D, Stumpf, Michael P.H
openaire   +2 more sources

Identification of genes related to intramuscular fat content of pigs using genome-wide association study [PDF]

Asian-Australasian Journal of Animal Sciences, 2018
Objective The aim of this study is to identify single nucleotide polymorphisms (SNPs) and genes related to pig IMF and estimate the heritability of intramuscular fat content (IMF). Methods Genome-wide association study (GWAS) on 704 inbred Berkshires was
Sohyoung Won, Jaehoon Jung, Eungwoo Park, Heebal Kim   +3 more
doaj   +1 more source

A publication-wide association study (PWAS), historical language models to prioritise novel therapeutic drug targets

Scientific Reports, 2023
Most biomedical knowledge is published as text, making it challenging to analyse using traditional statistical methods. In contrast, machine-interpretable data primarily comes from structured property databases, which represent only a fraction of the ...
David Narganes-Carlón, Daniel J. Crowther, Ewan R. Pearson   +2 more
doaj   +1 more source

Population genomics of helminth parasites

Journal of Helminthology, 2023
Abstract Next generation sequencing technologies have facilitated a shift from a few targeted loci in population genetic studies to whole genome approaches. Here, we review the types of questions and inferences regarding the population biology and evolution of parasitic helminths being addressed within the field of population genomics.
C.S. Thorn, R.W. Maness, J.M. Hulke, K.E. Delmore, C.D. Criscione   +4 more
openaire   +2 more sources

Genomic history of the Sardinian population [PDF]

Nature Genetics, 2018
The population of the Mediterranean island of Sardinia has made important contributions to genome-wide association studies of complex disease traits and, based on ancient DNA studies of mainland Europe, Sardinia is hypothesized to be a unique refuge for early Neolithic ancestry. To provide new insights on the genetic history of this flagship population,
Chiang Charleston W K, Marcus Joseph H, Sidore Carlo, Biddanda Arjun, AlAsadi Hussein, Zoledziewska Magdalena, Pitzalis Maristella, Busonero Fabio, Maschio Andrea, Pistis Giorgio, Steri Maristella, Angius Andrea, Lohmueller Kirk E, Abecasis Goncalo R, Schlessinger David, Cucca Francesco, Novembre John   +16 more
openaire   +3 more sources

Population genomics in neglected malaria parasites

Frontiers in Microbiology, 2022
Malaria elimination includes neglected human malaria parasites Plasmodium vivax, Plasmodium ovale spp., and Plasmodium malariae. Biological features such as association with low-density infection and the formation of hypnozoites responsible for relapse ...
Awtum M. Brashear, Liwang Cui
doaj   +1 more source

Is ‘likely pathogenic’ really 90% likely? Reclassification data in ClinVar

Genome Medicine, 2019
In 2015, professional guidelines defined the term ‘likely pathogenic’ to mean with a 90% chance of pathogenicity. To determine whether current practice reflects this definition, ClinVar classifications were tracked from 2016 to 2019.
Steven M. Harrison, Heidi L. Rehm
doaj   +1 more source