Results 121 to 130 of about 7,777,750 (304)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Racial Difference in the Relationship Between Health and Happiness in the United States
Psychology Research and Behavior Management, 2020 Sharon Cobb,1 Arash Javanbakht,2 Ebrahim Khalifeh Soltani,3 Mohsen Bazargan,4,5 Shervin Assari4 1School of Nursing, Charles R Drew University of Medicine and Science, Los Angeles, CA, USA; 2Department of Psychiatry and Behavioral Neurosciences, Wayne ...
Cobb S +4 more
doaj
Linking Population, Fertility and Family Planning with Adaptation to Climate Change: Views from Ethiopia [PDF]
, 2009 As global climate change unfolds, its effects are being felt disproportionately in the world's poorest countries and among the groups of people least able to cope.
Aklilu Kidanu +2 more
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Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Condom Programs in High HIV Prevalence Countries Should Include the General Population [PDF]
, 2004 This issue brief focuses on the principle that condoms should be promoted to the general population as well as high-risk groups, particularly in places with high HIV ...
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Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Leveraging information between multiple population groups and traits improves fine-mapping resolution. [PDF]
Nat Commun, 2023 Zhou F +6 more
europepmc +2 more sources
The Mexican-American Boom: Births Overtake Immigration [PDF]
, 2011 Analyzes population growth, fertility, and immigration trends among Mexican Americans since 1980 compared with those of other U.S. groups and Mexico.
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Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source