Results 161 to 170 of about 13,735,667 (283)

Clinically Relevant Pharmacogenomic Variant Frequencies in Kazakh, Russian, and Uzbek Population Groups Residing in Kazakhstan. [PDF]

Biology (Basel)
Zhaniyazov Z, Kulatayeva A, Mustafayeva A, Aulbekova A, Altynova N, Zhunussova G, Abdullayeva M, Ryspaeva S, Mangazbayeva R, Daribayev B, Mukhambetzhanov S, Djansugurova L.   +11 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Dietary phosphate exposure-strategies to protect vulnerable population groups. [PDF]

Arch Toxicol
Lampen A, Lachenmeier DW, Diel P, Ensenauer R, Frommherz L, Guth S, Humpf HU, Kulling SE, Villar-Fernández MA, Wätjen W, Mally A, Steinberg P.   +11 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Which population groups are more likely to get too little sleep? Results of the 'German Health Update' (GEDA 2023). [PDF]

J Health Monit
Kaufholdová N, Richter A, Saß AC, Schienkiewitz A.   +3 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Effects of active travel interventions in the UK on disadvantaged population groups and their potential to reduce health inequalities: systematic review. [PDF]

J Epidemiol Community Health
Hollands GJ, Macdowall W, Burchett HE, Kwan I, D'Souza P, Richardson M, Stansfield C, Ogilvie D, Panter J, Thomas J, Sowden AJ, Sutcliffe K.   +11 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Depressive Symptoms and Utilization of Mental Health Services among Older Israelis Across Population Groups. [PDF]

Transcult Psychiatry
Elbaz H, Saphier Y, Dolberg P, Kučera M, Kearns PB.   +4 more
europepmc   +1 more source

COVID and depression among stratified population groups: a narrative review. [PDF]

Eur J Med Res, 2023
Charul, Raina JK, Sharma S, Pal S, Dogra V, Kumar P, Panjaliya RK.   +6 more
europepmc   +1 more source