Results 201 to 210 of about 13,735,667 (283)

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Mpox Seroprevalence in General Population Groups in South Kivu, Democratic Republic of the Congo: A Comparative Description Before and During the Clade Ib Outbreak. [PDF]

Open Forum Infect Dis
Nkuba-Ndaye A, Biai N, Kwakanaba-Mweze A, Lupande-Mwenebitu D, Chasinga-Buharanyi T, Ayagirwe-Basengere R, Mukanya-Mulopo N, Tsiwedi-Tsilabia E, Kavira-Muhindo MA, Mputu-Ngoyi B, Ndomba-Mukanya E, Kwizera-Sendegeya J, Glénat L, Bulabula-Penge J, Thaurignac G, Mukadi-Bamuleka D, LeMarcis F, Ayouba A, Delaporte E, Peeters M, Mari-Saez A, Ahuka-Mundeke S.   +21 more
europepmc   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Ground-Level Ozone as Community-Acquired Pneumonia Risk Factor in Different Population Groups in Summer: The Case of Moscow. [PDF]

Toxics
Dudorova N, Belan B, Kotel'nikov S.
europepmc   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Barriers and Opportunities to Include Underrepresented Population Groups in Vaccine Trials: Cross-Sectional, Observational, Online Survey Study From the VACCELERATE Research Network. [PDF]

JMIR Public Health Surveill
Tanriover MD, Poulimeneas D, Tsopela GC, Kopsidas I, Argyropoulos C, Di Marzo R, Valdenmaiier O, Jakobsen SF, Valle Simon P, Carcas-Sansuan AJ, Olesen OF, Cornely OA, Pana ZD, Zaoutis T, Akova M.   +14 more
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Occurrence and Dietary Exposure Assessment of Quinolone Antibiotics in Animal-Derived Foods and Associated Health Risks Among Different Population Groups in Guangzhou, China. [PDF]

Foods
Xie Z, Wang Y, Chen Y, Li Y, Zhang Y, Liu L, Peng R, Zhang W, Mao YH.   +8 more
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Sorting out assortativity: When can we assess the contributions of different population groups to epidemic transmission? [PDF]

PLoS One
Geismar C, White PJ, Cori A, Jombart T.
europepmc   +2 more sources