Results 141 to 150 of about 374,493 (293)
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The Astrophysical JournalPrimordial black holes (PBHs) in the asteroid mass window from 10 ^−16 M _⊙ to 10 ^−10 M _⊙ are currently a popular dark matter candidate. If they exist, some stars would capture them upon formation, and they would slowly accrete the star over gigayears.
Andrew D. Santarelli +2 more
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
New Stellar Parameters, Metallicities, and Elemental Abundance Ratios for 311 Metal-poor Stars
The Astronomical JournalWe present equivalent widths, improved model atmosphere parameters, and revised abundances for 14 species of 11 elements derived from high-resolution optical spectroscopy of 311 metal-poor stars.
Sanil Mittal, Ian U. Roederer
doaj +1 more source
Carbon-rich, extremely metal-poor Population II stars
, 2002 4 pages including 1 figure. Conference proceedings for "CNO in the Universe", St Luc, Switzerland, 10-14 September 2002 C. Charbonnel, D. Schaerer & G.
openaire +2 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Aeos Is Mixing It Up: The (In)homogeneity of Metal Mixing Following Population III Star Formation
The Astrophysical JournalStellar surface abundances are records of the state of the gas from which stars formed and thus trace how individual elements have mixed into the surrounding medium following their ejection from stars.
Jennifer Mead +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source