Results 141 to 150 of about 11,182,421 (303)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

What can magnetic early B-type stars tell us about early B-type stars in general?

, 2016
Some magnetic early B-type stars display Hα emission originating in their Centrifugal Magnetospheres (CMs). To determine the rotational and magnetic properties necessary for the onset of emission, we analyzed a large spectropolarimetric dataset for a ...
Grunhut, Jason, Wade, Gregg,, Alecian, Evelyne,, Jason Grunhut, Evelyne Alecian, Neiner, Coralie,, Petit, Veronique,, Gregg Wade, Rivinius, Thomas,, Wade, Gregg, null null, Neiner, Coralie, Grunhut, Jason,, Coralie Neiner, Alecian, Evelyne, Matthew Shultz, Thomas Rivinius, Rivinius, Thomas, Véronique Petit, Shultz, Matthew,, Binamics Collaboration, ., Shultz, Matthew E., Petit, Veronique   +22 more
core   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Origin of α-poor Very Metal-poor Stars

The Astrophysical Journal
Among very metal-poor (VMP) stars, α -poor VMP ( α -PVMP) stars that have subsolar values of [X/Fe] for Mg and other α elements are rare and are thought to have been formed from gas polluted by Type 1a supernova (SN 1a). However, recent analyses indicate
S. K. Jeena, Projjwal Banerjee
doaj   +1 more source

Type II Cepheids: period-luminosity-metallicity relations for the Population II distance scale

Frontiers in Astronomy and Space Sciences
Type II Cepheids are a class of pulsating variable stars that play a critical role in our understanding of stellar evolution, distance measurement and tracing the structure and kinematics of old stars in nearby galaxies.
Susmita Das, Susmita Das, Susmita Das, Anupam Bhardwaj, Marcella Marconi   +4 more
doaj   +1 more source

Mg II h + k Flux—Rotational Period Correlation for G-type Stars

, 2013
We present an analysis of the correlation between the mid-UV Mg II h and k emission lines and measured rotational periods of G-type stars. Based on IUE and HST high resolution spectra of a sample of 36 stars, we derive an exponential function that best ...
JOSE MANUEL OLMEDO AGUILAR, MIGUEL Y ROSA MARIA CHAVEZ DAGOSTINO, Emanuele Bertone, Víctor Hugo de la Luz Rodríguez   +3 more
core