Results 121 to 130 of about 11,182,421 (303)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Type Ia Supernovae from First-generation Stars

The Astrophysical Journal
Type Ia supernovae (SNe Ia) discovered at redshift z ≲ 2.5 are presumed to be produced from Population I/II stars. In this work, we investigate the production of SNe Ia from Population III binaries in the cosmological framework.
Zhenwei Li, Lifan Wang, Zhanwen Han, Xuefei Chen   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Sloan Digital Sky Survey IV MaStar: Quantification and Abatement of Interstellar Absorption in the Largest Empirical Stellar Spectral Library

The Astrophysical Journal
We assess the impact of Ca ii λ λ 3934, 3969 and Na i λ λ 5891, 5897 absorption arising in the interstellar medium (ISM) on the Sloan Digital Sky Survey-IV MaNGA Stellar Library (MaStar) and produce corrected spectroscopy for 80% of the 24,162-star ...
Kate H. R. Rubin, Kyle B. Westfall, Claudia Maraston, Daniel Thomas, Renbin Yan, J. Christopher Howk, Erick Aguirre, Kaelee S. Parker, David R. Law   +8 more
doaj   +1 more source

A DECam view of the diffuse dwarf galaxy Crater II – Variable stars

, 2020
Time series observations of a single dithered field centred on the diffuse dwarf satellite galaxy Crater II were obtained with the Dark Energy Camera (DECam) at the 4m Blanco Telescope at Cerro Tololo Inter-American Observatory, Chile, uniformly covering
Monelli, Matteo, Nidever, David L., Braga, Vittorio F., Fiorentino, Giuliana, Stetson, Peter B., Andreuzzi, Gloria, Bono, Giuseppe, Dorta, Antonio, Vivas, A. Katherina, Gallart, Carme, Dall’Ora, Massimo, Olsen, Knut, Martínez-Vazquez, Clara E., Walker, Alistair R.   +13 more
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Black hole–neutron star and binary neutron star mergers from Population III and II stars

Population III (Pop. III) stars are expected to be massive and to undergo minimal mass loss due to their lack of metals, making them ideal progenitors of black holes and neutron stars.
Branchesi M., Paiella L., Mould M., Iorio G., Liu B., Mapelli M., Mestichelli B., Lipatova V., Costa G., Santoliquido F., Arca Sedda M., Klessen R. S.   +11 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source