Results 121 to 130 of about 374,493 (293)
The Astrophysical JournalWide-field photometry of Galactic globular clusters (GCs) has been investigated to overcome limitations from the small field of view of the Hubble Space Telescope in the study of multiple populations.
S. Jang +12 more
doaj +1 more source
Astronomy & AstrophysicsRecent work has established large samples of astrometrically confirmed RR Lyrae and type-II Cepheid members of Galactic globular clusters (GCs). Any given GC can contain multiple such stars at once, notably RR Lyrae stars pulsating in the fundamental ...
Lengen Bastian +3 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Spectacular Nucleosynthesis from Early Massive Stars
The Astrophysical Journal LettersStars that formed with an initial mass of over 50 M _⊙ are very rare today, but they are thought to be more common in the early Universe. The fates of those early, metal-poor, massive stars are highly uncertain.
Alexander P. Ji +41 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Hidden Population III Descendants in Ultrafaint Dwarf Galaxies
The Astrophysical JournalThe elusive properties of the first (Population III or Pop III) stars can be indirectly unveiled by uncovering their true descendants. To this end, we exploit our data-calibrated model for the best-studied ultrafaint dwarf galaxy (UFD), Boötes I, which ...
Martina Rossi +4 more
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Type II Cepheids: period-luminosity-metallicity relations for the Population II distance scale
Frontiers in Astronomy and Space SciencesType II Cepheids are a class of pulsating variable stars that play a critical role in our understanding of stellar evolution, distance measurement and tracing the structure and kinematics of old stars in nearby galaxies.
Susmita Das +4 more
doaj +1 more source