Results 111 to 120 of about 374,493 (293)

The First Population II Stars Formed in Externally Enriched Mini-halos

, 2015
We present a simulation of the formation of the earliest Population II stars, starting from cosmological initial conditions and ending when metals created in the first supernovae are incorporated into a collapsing gas-cloud. This occurs after a supernova
Khochfar, Sadegh, Norman, Michael, O'Shea, Brian, Smith, Britton, Wise, John   +4 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Extended Stellar Populations in Ultrafaint Dwarf Galaxies

The Astronomical Journal
The possible existence of stellar halos in low-mass galaxies is being intensely discussed nowadays after some recent discoveries of stars located in the outskirts of dwarf galaxies of the Local Group.
Elisa A. Tau, A. Katherina Vivas, Clara E. Martínez-Vázquez   +2 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

A Metallicity Catalog of Very Metal-poor Main-sequence Turn-off and Red Giant Stars from LAMOST DR10

The Astrophysical Journal Supplement Series
We present a catalog of 8440 candidate very metal-poor (VMP; [Fe/H] ≤ −2.0) main-sequence turn-off (MSTO) and red giant stars in the Milky Way, identified from low-resolution spectra in LAMOST DR10. More than 7000 of these candidates are brighter than G  
Xiangyu Li, Huiling Chen, Yang Huang, Huawei Zhang, Timothy C. Beers, Linxuan Zhu, Jifeng Liu   +6 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Classification of Population II Stars in the RGU System [PDF]

Symposium - International Astronomical Union, 1973
The theoretical treatment of the blanketing effect and the first photometric results had shown that the separation of stars of different metal content should be better in the RGU system than in the UBV system. A three color photometry of the globular cluster M5 is undertaken to show the position of these stars in the RGU two-color diagram, to derive ...
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Black hole--neutron star and binary neutron star mergers from Population III and II stars

Astronomy & Astrophysics
Population III (Pop. III) stars are expected to be massive and to undergo minimal mass loss due to their lack of metals, making them ideal progenitors of black holes and neutron stars. Here, we investigate the formation and properties of binary neutron star (BNS) and black hole--neutron star (BHNS) mergers originating from Pop.
Mestichelli, Benedetta, Mapelli, Michela, Santoliquido, Filippo, Sedda, Manuel Arca, Branchesi, Marica, Paiella, Lavinia, Costa, Guglielmo, Iorio, Giuliano, Mould, Matthew, Lipatova, Veronika, Liu, Boyuan, Klessen, Ralf S.   +11 more
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source