Results 91 to 100 of about 374,493 (293)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Variable Stars and Galactic Structure

, 2013
Variable stars have a unique part to play in Galactic astronomy. Among the most important of these variables are the Cepheids (types I and II), the RR Lyraes and the Miras (O- and C-rich).
Feast, Michael W., Whitelock, Patricia A.   +1 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Compact Star Clusters in M81. II. Two Populations

The Astronomical Journal, 2001
We present the color and magnitude distributions of compact star clusters discovered in the early-type spiral galaxy M81, from Hubble Space Telescope Wide Field Planetary Camera 2 B, V, and I-band imaging. These clearly show the presence of two cluster populations—a typical red globular cluster system, as well as a young population, which was not ...
Rupali Chandar, Zlatan Tsvetanov, Holland C. Ford   +2 more
openaire   +1 more source

The First Galaxies: Chemical Enrichment, Mixing, and Star Formation

, 2010
Using three-dimensional cosmological simulations, we study the assembly process of one of the first galaxies, with a total mass of 10^8 M_sun, collapsing at z = 10.
Abrahamsson, Ahn, Alvarez, Alvarez, Barkana, Boley, Bromm, Bromm, Cen, Cherchneff, Clark, Clark, Dijkstra, Frebel, Frebel, Glover, Greif, Haiman, Haiman, Heger, Helmi, Jappsen, Jappsen, Jappsen, Johnson, Karlsson, Kudritzki, Mackey, Madau, McKee, Monaghan, Navarro, Nozawa, Omukai, O’Shea, O’Shea, O’Shea, Puzia, Ralf S. Klessen, Santoro, Schaye, Shen, Simon C. O. Glover, Spergel, Thomas H. Greif, Tormen, Tumlinson, Volker Bromm, Whalen, Whalen, Whalen, Whalen, Wise, Wise, Yoshida, Yoshida   +55 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Type Ia Supernovae from First-generation Stars

The Astrophysical Journal
Type Ia supernovae (SNe Ia) discovered at redshift z ≲ 2.5 are presumed to be produced from Population I/II stars. In this work, we investigate the production of SNe Ia from Population III binaries in the cosmological framework.
Zhenwei Li, Lifan Wang, Zhanwen Han, Xuefei Chen   +3 more
doaj   +1 more source

Constraining the structure and formation of the Galactic bulge from a field in its outskirts. FLAMES-GIRAFFE spectra of about 400 red giants around (l,b)=(0{\deg},-10{\deg})

, 2012
The presence of two stellar populations in the Milky Way bulge has been reported recently. We aim at studying the abundances and kinematics of stars in the outer bulge, thereby providing additional constraints on models of its formation.
Chen, B., Lebzelter, Thomas, Nataf, David. M., Robin, Annie C., Schultheis, Mathias, Uttenthaler, Stefan   +5 more
core   +3 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source