Results 191 to 200 of about 24,585 (264)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Prognostic value of DNA methylation in head and neck cancer: a systematic review and meta-analysis. [PDF]

Transl Cancer Res
Che M, Tang D, Zhang R.
europepmc   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Differentiation of <i>Lupinus</i> and <i>Mimosa</i> by Machine Learning Employing Spectroscopic Data: A Comparative Study. [PDF]

ACS Omega
Koetz M, Vendruscolo MH, Maia AK, Martinelli SLK, González M, Sasaki MK, Miotto STS, Scopel M, de Oliveira Alves E, Viegas RM, Fuentefria AM, Ferrão MF, Zuanazzi JAS.   +12 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Subchronic Cadmium-Induced Xenobiotic Toxicity in Male Wistar Rats: Antioxidant and Reproductive Protection by Standardized Silymarin with Molecular Docking Insights. [PDF]

J Xenobiot
Hammami I, Arrari F, Mahjoub R, Ali RB, Hentati HE, Nahdi A, López-Maldonado EA, Talbi E.   +7 more
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

A Faint Progenitor System for the Faint Supernova 2024vjm

Zimmerman E, Gal-Yam A, Groot P, Ofek E, Roestel Jv, Pastorello A, Valenti S, Ravi A, Chen P, Schulze S, Blagorodnova N, Wavasseur M, Gómez-Muñoz M, Tranin H, de Wet S, Leloudas G, Vreeswijk P, Kwok L, Schwab M, Jha S, Maguire K, Sand D, Stringer E, Kupfer T, Faran T, Anderson J, Andrews J, Andrews M, Badash A, Bloemen S, Bostroem K, Chen T, Valle MD, Dimitriadis G, Dong Y, Farah J, Gillanders J, Godson B, Gromadzki M, Hiramatsu D, Hoang E, Howell D, Janzen D, Kuncarayakti H, Li J, Lyman J, Maeda K, Magee M, Mehta D, Milligan A, Moran S, Ni YQ, O’Neill D, Pearson J, Pieterse D, Pignata G, Reguitti A, Reichart D, Retamal NM, Santos R, Scaringi S, Shrestha M, Srivastav S, Stoppa F, Subrayan B, Valerin G, Wang X, Wynn K, Yaron O, Zang W.   +69 more
europepmc   +1 more source

Causal AI-based clinical and radiomic analysis for optimizing patient selection in combined immunotherapy and SABR in early-stage NSCLC: a secondary analysis of the phase II I-SABR trial. [PDF]

J Immunother Cancer
Saad MB, Showkatian E, Verma V, Al-Tashi Q, Aminu M, Xu X, Qayati Mohamed M, Salehjahromi M, Sujit SJ, Kitsel Y, Lin SH, Liao Z, Gandhi S, Qian D, Jaffray D, Chung C, Vokes NI, Zhang J, Lee JJ, Heymach JV, Wu J, Chang JY.   +21 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source