Results 211 to 220 of about 374,493 (293)

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Progression from uncomplicated to severe malaria among children in settings receiving different combinations of malaria control interventions in sub-Saharan Africa: a systematic review and meta-analysis. [PDF]

Trop Med Health
Okek EJ, Jehopio J, Sande OJ, Musinguzi B, Awor S, Asio J, Le DK, Lutwama J, Alison AK, Bongomin F, Ocan M, Kayondo J.   +11 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Common and recurrent dysregulated molecular network of placental hypoxia and associated vasculogenesis and angiogenesis in fetal growth restriction. [PDF]

Front Endocrinol (Lausanne)
Li W, Bai X, Chan OK, Leung MBW, Lau SL, Wang CC, Leung TY.   +6 more
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

A nutrient bottleneck controls antibiotic efficacy in structured bacterial populations. [PDF]

Nat Commun
Hancock AM, Dill-Macky AS, Moore JA, Day C, Donia MS, Datta SS.   +5 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

A Faint Progenitor System for the Faint Supernova 2024vjm

Zimmerman E, Gal-Yam A, Groot P, Ofek E, Roestel Jv, Pastorello A, Valenti S, Ravi A, Chen P, Schulze S, Blagorodnova N, Wavasseur M, Gómez-Muñoz M, Tranin H, de Wet S, Leloudas G, Vreeswijk P, Kwok L, Schwab M, Jha S, Maguire K, Sand D, Stringer E, Kupfer T, Faran T, Anderson J, Andrews J, Andrews M, Badash A, Bloemen S, Bostroem K, Chen T, Valle MD, Dimitriadis G, Dong Y, Farah J, Gillanders J, Godson B, Gromadzki M, Hiramatsu D, Hoang E, Howell D, Janzen D, Kuncarayakti H, Li J, Lyman J, Maeda K, Magee M, Mehta D, Milligan A, Moran S, Ni YQ, O’Neill D, Pearson J, Pieterse D, Pignata G, Reguitti A, Reichart D, Retamal NM, Santos R, Scaringi S, Shrestha M, Srivastav S, Stoppa F, Subrayan B, Valerin G, Wang X, Wynn K, Yaron O, Zang W.   +69 more
europepmc   +1 more source

Demographic and anatomic predictors of glenoid morphology: a systematic review. [PDF]

JSES Rev Rep Tech
Prakash R, Aagesen AL, Javed N, Yanik EL, Jain NB.   +4 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source