Results 231 to 240 of about 374,493 (293)

Arrhythmic risk in mitral valve prolapse with mitral annular disjunction: meta-analysis of longitudinal studies. [PDF]

Sci Rep
Chianese S, Ordine L, Pacella D, Canciello G, Di Napoli S, Lombardi R, Esposito G, Losi MA.   +7 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Mental health outcomes in patients with inherited retinal diseases: a systematic review and meta-analysis. [PDF]

Int J Retina Vitreous
Abu Serhan H, Ahmed A, Sbei O, Kojan W, Chaudhry M, Khalid M, Sheraz A, Al-Moujahed A.   +7 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

The second survey of the Saudi Acute Myocardial Infarction Registry Program: Main results and temporal changes in care (STARS-2 program). [PDF]

PLoS One
AlSaleh A, AlSaif SM, Alhadramy O, Alshehri M, Al Faraidy K, Almutairi F, Kinsara AJ, Al-Murayeh M, Ghabashi AE, Alasnag M, Hussein GA, Askar TM, Haider KH, Alharbi IA, Almokhlef A, Sayed BA, Almasswary A, Ul-Sabah Z, Kazim H, Albareda HA, Aldossari MA, Albawardi R, Alali R, Abdulhabeeb IAM, Ibrahim SM, Alasmari S, Almoghairi AM, Khoja AY, Hussain N, Aminu BS, Serafi A, Eltayeb AO, BuSaleh AH, Alsabatien B, Hamza MK, Alsharkawy R, Awwad AA, Mohamed MA, Al Habeeb MA, Shujauddin S, Ya'u JA, Attia NM, Kholaif N, Bin Ghouth NM, Youssef MKI, Qutub MA, Lawand SR, Alkutshan R, Ahmed E, Basardah A, Alhaj WI, Altaradi H, Ali M, Alqarawi W, Alhabib KF, STARS-2 Investigators.   +55 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Associations of three immune inflammatory markers with the risk of brain metastasis from lung cancer: a systematic review and meta-analysis. [PDF]

Front Oncol
Liu M, Shi Y, Chen A, Hu X.
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Hyperbilirubinemia as a Marker for Complicated Acute Appendicitis: A Systematic Review. [PDF]

Cureus
Czyszczon A, Maczkowski B, Tkaczyk A, Drozdz M, Boral W, Mikler S, Mandyna M, Przelaskowska A, Pulinski J.   +8 more
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source