Results 31 to 40 of about 6,060,767 (257)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

New Zealand regions, 1986-2001: Population dynamics [PDF]

, 2005
New Zealand regions have markedly different population dynamics. Population change in a region is driven by three different factors: fertility, mortality and migration.
Lindop, J., Pool, Ian, Baxendine, Sandra, Cochrane, William   +3 more
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

International migration in a sea of islands: Challenges and opportunities for insular Pacific spaces [PDF]

, 2008
Our contribution to the International Conference “Connecting Worlds: Emigration, Immigration and Development in Insular Spaces”, held in the Azores between 28 and 30 May 2008, examines contemporary mobility of Pacific peoples in a transnational context ...
Hugo, Graeme, Bedford, Richard
core  

Modeling China’s Urban Network Structure: Unraveling the Drivers from a Population Mobility Perspective

Systems
Intercity population flows are playing an increasingly pivotal role in shaping the spatial evolution and structural dynamics of urban networks. Drawing upon Amap Migration Data (2018–2023), this study maps China’s urban networks using social network ...
Haowei Duan, Kai Liu
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Spatiotemporal dynamics of HIV-1 transmission networks in a major migration hub: integrated phylogenetic and molecular evidence

Frontiers in Microbiology
ObjectiveHuman Immunodeficiency Virus type 1 (HIV-1) cross-regional transmission poses a critical challenge in China, particularly in high-mobility metropolitan centers.
Min Zhu, Min Zhu, Junfang Chen, Zhou Sun, Ke Xu, Ke Xu, Xingliang Zhang, Sisheng Wu, Ling Ye, Ling Ye, Xiaojuan Xu, Wenjie Luo   +11 more
doaj   +1 more source

A Machine Learning Evaluation of the Effects of South Africa’s COVID-19 Lockdown Measures on Population Mobility

Machine Learning and Knowledge Extraction, 2021
Following the declaration by the World Health Organisation (WHO) on 11 March 2020, that the global COVID-19 outbreak had become a pandemic, South Africa implemented a full lockdown from 27 March 2020 for 21 days.
Albert Whata, Charles Chimedza
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source