Results 231 to 240 of about 215,808 (286)

Population pharmacokinetics and Monte Carlo-based dosing optimization of trimethoprim-sulfamethoxazole. [PDF]

Antimicrob Agents Chemother
Chen B, Chen Y, Chen M, Mao Y, Huang Y, Zhou L, Wu W, Li X, Wu X, Cheng Y, Qiu H.   +10 more
europepmc   +1 more source

Heterogenous Model of Temozolomide Resistance in Glioblastoma Reveals Phenotypic Shifts in Drug Response and Migratory Potential

Advanced NanoBiomed Research, EarlyView.
Glioblastoma mortality is driven by cell invasion and therapeutic resistance. We report a cancer engineering approach to evaluate the behavior of heterogeneous cohorts of temozolomide resistant and responsive GBM cells. We show the effect of physiologically‐relevant metronomic dosing on ensemble drug response and invasion.
Victoria A. Kriuchkovskaia, Ela K. Eames, Sydney A. McKee, Paul J. Hergenrother, Rebecca B. Riggins, Brendan A. C. Harley   +5 more
wiley   +1 more source

Population pharmacokinetics of lumefantrine in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum malaria in Western Kenya. [PDF]

Br J Clin Pharmacol
Juma E, Ding J, Ongas M, Koskei N, Onyango K, Oloo F, Aman R, Kokwaro G, Tarning J, Ogutu B.   +9 more
europepmc   +1 more source

Identification of Histone Deacetylase Inhibitor Targeting Type I Interferon and B Cell Abnormalities in Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective Systemic lupus erythematosus (SLE) is characterized by increased Type I interferon (IFN‐I) and autoantibody production. This study aimed to identify drugs that can inhibit both IFN‐I and autoantibody production. Methods We identified an inhibitor of IFN‐I production from a chemical library.
Takehiro Hirayama, Hachiro Konaka, Yasuhiro Kato, Takayuki Shibahara, Chisato Nishizawa, Kohei Tsujimoto, JeongHoon Park, Eri Itotagawa, Tatsunori Jo, Masayuki Nishide, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Wataru Aoki, Ken J Ishii, Hyota Takamatsu, Atsushi Kumanogoh   +16 more
wiley   +1 more source

Bridging Literature and Real-World Evidence: External Evaluation and Development of Fluoxetine Population Pharmacokinetics Model. [PDF]

Pharmaceutics
Han B, Xu N, Ma C, Ju G, Xi X, Qian C, Guo N, Liu X, Zhu X, Li C, Liu L.   +10 more
europepmc   +1 more source

Oral Cephalexin Population Pharmacokinetics and Target Attainment Analysis in Infants 7-60 Days Old. [PDF]

J Pediatric Infect Dis Soc
Haynes AS, Wei Z, Scheetz MH, Gonzalez D, Messacar K, Tang Girdwood S, Peloquin CA, Fish DN, Anderson P.   +8 more
europepmc   +1 more source

Efficacy and Safety of Subcutaneous Anifrolumab in Systemic Lupus Erythematosus: A Randomized, Phase 3 Study

Arthritis &Rheumatology, EarlyView.
Objective The multinational, phase 3, double‐blind, placebo‐controlled TULIP‐SC trial evaluated the efficacy and safety of subcutaneous anifrolumab in adults who have moderate to severe systemic lupus erythematosus (SLE) activity, despite receiving standard therapy. Methods Adults with SLE received subcutaneous anifrolumab 120 mg or placebo once weekly
Susan Manzi, Ian N. Bruce, Eric F. Morand, Richard Furie, Yoshiya Tanaka, Kenneth C. Kalunian, Anca Askanase, Patricia Puzio, Emon Khan, Jenny Wissmar, Michael Song, Catharina Lindholm, for the TULIP‐SC investigators   +12 more
wiley   +1 more source

Population pharmacokinetics modelling to predict DDI from zopiclone on clozapine in schizophrenia patients. [PDF]

Front Psychiatry
Han HH, Zhang Y, Wang J, Tian X, Li Y, He SM, Zhang C, Chen X, Wang DD.   +8 more
europepmc   +1 more source

Serum Proteomic Signatures of Rheumatoid Arthritis Risk and Response: Analysis of a Rheumatoid Arthritis Interception Trial

Arthritis &Rheumatology, EarlyView.
Objective Our study objective was to identify serum protein signatures associated with progression to rheumatoid arthritis (RA) and response to abatacept in at‐risk individuals. Methods A total of 440 serum samples from 118 APIPPRA (Arthritis Prevention In the Preclinical Phase of RA with Abatacept) study participants were selected from baseline to RA ...
Marianna Jasenecova, Carl Coyle, Alina Mihalovits, Sarah Ryan, Elizabeth Pook, Esperanza Perucha, Gabrielle Harker, Melody Chin, Sam Norton, Andrew P. Cope   +9 more
wiley   +1 more source

Population Pharmacokinetics Model of Cyclosporin A in Children and Young Adult Renal Transplant Patients: Focus on Haemoglobin Contribution to Exposure Variability. [PDF]

Pharmaceutics
Roganović M, Cvetković M, Gojković I, Spasojević B, Jovanović M, Miljković B, Vučićević K.   +6 more
europepmc   +1 more source