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Population pharmacokinetics of vancomycin in neonates
Clinical Pharmacology and Therapeutics, 1994To determine population pharmacokinetic parameters of vancomycin in neonates.This was a retrospective design, with prospective validation. Two hundred ten sequential neonates were evaluated at the neonatal intensive care units of Minneapolis Children's Medical Center and Children's Hospital of St. Paul. Five hundred twenty serum concentrations from 192
R E, Seay +4 more
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Population Pharmacokinetic Analysis of Bisoprolol
Clinical Pharmacokinetics, 1989The technique of population pharmacokinetic analysis was employed to study the variability in the dose concentration relationship of bisoprolol during its clinical development. The influence of demographic factors on the variability of clearance was investigated in 3 different populations: group I, patients (including an elderly group) with essential ...
J, Grevel, P, Thomas, B, Whiting
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Abstract The role of population pharmacokinetics in drug development is introduced.
Phil Ambery +2 more
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Phil Ambery +2 more
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Population pharmacokinetics of sirolimus
Clinical Pharmacology & Therapeutics, 1998G M, Ferron +3 more
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Population Pharmacokinetics/Dynamics*
Annual Review of Pharmacology and Toxicology, 1992L B, Sheiner, T M, Ludden
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Population pharmacokinetics of etoposide*
Int. Journal of Clinical Pharmacology and Therapeutics, 2002S, Reif +6 more
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International journal of clinical pharmacology, therapy, and toxicology, 1993
Traditionally pharmacokinetic studies have been performed in small homogenous groups of subjects, often normal healthy, young male volunteers. These studies are well controlled and generate meaningful baseline data. However, concern has been expressed that insufficient data is collected at an early state in the target population during a drug's ...
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Traditionally pharmacokinetic studies have been performed in small homogenous groups of subjects, often normal healthy, young male volunteers. These studies are well controlled and generate meaningful baseline data. However, concern has been expressed that insufficient data is collected at an early state in the target population during a drug's ...
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Pharmacokinetics of remimazolam after intravenous infusion in anaesthetised children
British Journal of Anaesthesia, 2023Jürgen Schüttler +2 more
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